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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Hormad2tm1Kura
targeted mutation 1, Hiroki Kurahashi
MGI:5466566
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Hormad2tm1Kura/Hormad2tm1Kura either: B6.Cg-Hormad2tm1Kura or (involves: C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj) MGI:5466572
cx2
 		Hormad2tm1Kura/Hormad2+
Spo11tm1Mjn/Spo11tm1Mjn 		involves: 129X1/SvJ * C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj MGI:5466573
cx3
 		Hormad2tm1Kura/Hormad2tm1Kura
Spo11tm1Mjn/Spo11tm1Mjn 		involves: 129X1/SvJ * C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj MGI:5466574


Genotype
MGI:5466572
hm1
Allelic
Composition		 Hormad2tm1Kura/Hormad2tm1Kura
Genetic
Background		 either: B6.Cg-Hormad2tm1Kura or (involves: C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hormad2tm1Kura mutation (1 available); any Hormad2 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:192634 )
N
• female mice are fertile with normal ovary morphology
abnormal female meiosis ( J:192634 )
• incomplete synapsis in pachytene oocytes of fetal females
abnormal male meiosis ( J:192634 )
• more pachytene spermatocytes contain one or a few chromosomes pairs with incomplete synapsis than in wild-type mice
• pachytene spermatocytes rarely exhibit a typical sex body unlike in wild-type mice
• disruption of meiotic sex chromosome inactivation in spermatocytes
• sex body formation in spermatocyte is impaired
abnormal male germ cell apoptosis ( J:192634 )
• confined to the stage IV seminiferous tubule

cellular
abnormal female meiosis ( J:192634 )
• incomplete synapsis in pachytene oocytes of fetal females
abnormal male meiosis ( J:192634 )
• more pachytene spermatocytes contain one or a few chromosomes pairs with incomplete synapsis than in wild-type mice
• pachytene spermatocytes rarely exhibit a typical sex body unlike in wild-type mice
• disruption of meiotic sex chromosome inactivation in spermatocytes
• sex body formation in spermatocyte is impaired
abnormal male germ cell apoptosis ( J:192634 )
• confined to the stage IV seminiferous tubule

endocrine/exocrine glands




Genotype
MGI:5466573
cx2
Allelic
Composition		 Hormad2tm1Kura/Hormad2+
Spo11tm1Mjn/Spo11tm1Mjn
Genetic
Background		 involves: 129X1/SvJ * C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hormad2tm1Kura mutation (1 available); any Hormad2 mutation (33 available)
Spo11tm1Mjn mutation (2 available); any Spo11 mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:192634 )
N
• unlike Spo11tm1Mjn homozygotes, ovarian weights are normal
decreased oocyte number ( J:192634 )
• not as severe as in Spo11tm1Mjn homozygotes
abnormal female meiosis ( J:192634 )
• pseudo-sex body formation in oocytes is impaired

cellular
decreased oocyte number ( J:192634 )
• not as severe as in Spo11tm1Mjn homozygotes
abnormal female meiosis ( J:192634 )
• pseudo-sex body formation in oocytes is impaired




Genotype
MGI:5466574
cx3
Allelic
Composition		 Hormad2tm1Kura/Hormad2tm1Kura
Spo11tm1Mjn/Spo11tm1Mjn
Genetic
Background		 involves: 129X1/SvJ * C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hormad2tm1Kura mutation (1 available); any Hormad2 mutation (33 available)
Spo11tm1Mjn mutation (2 available); any Spo11 mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:192634 )
N
• unlike Spo11tm1Mjn homozygotes, mice exhibit normal ovarian weights and oocyte numbers
abnormal female meiosis ( J:192634 )
• pseudo-sex body formation in oocytes is impaired
abnormal testis morphology ( J:192634 )
• as in single homozytoes

endocrine/exocrine glands
abnormal testis morphology ( J:192634 )
• as in single homozytoes

cellular
abnormal female meiosis ( J:192634 )
• pseudo-sex body formation in oocytes is impaired




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory