Phenotypes associated with this allele

• Allele Symbol: Mbd5^tm1.2Gxu
• Allele Name: targeted mutation 1.2, Guo-Liang Xu
• Allele ID: MGI:5466580
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mbd5^tm1.2Gxu/Mbd5^tm1.2Gxu	involves: 129S2/SvPas * C57BL/6J	MGI:5466592

Genotype
MGI:5466592

hm1

• Allelic Composition: Mbd5^tm1.2Gxu/Mbd5^tm1.2Gxu
• Genetic Background: involves: 129S2/SvPas * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Small body size of Mbd5^tm1.2Gxu/Mbd5^tm1.2Gxu mice

mortality/aging

postnatal lethality, complete penetrance ( J:192212 )

• mice die between P1 and P22

homeostasis/metabolism

decreased circulating insulin-like growth factor I level ( J:192212 )

• in newborn mice

abnormal glucose homeostasis ( J:192212 )

• after oral glucose tolerance tests, glucose absorption is delayed compared to in control mice

• mice exhibit enhanced liver glycolysis compared with control mice

decreased circulating glucose level ( J:192212 )

• in fed and fasted mice

hypoglycemia ( J:192212 )

decreased circulating insulin level ( J:192212 )

improved glucose tolerance ( J:192212 )

increased insulin sensitivity ( J:192212 )

decreased growth hormone level ( J:192212 )

• in the pituitary gland

growth/size/body

decreased body size ( J:192212 )

• postnatally

decreased body weight ( J:192212 )

• beginning 3 days after birth

cachexia ( J:192212 )

• postnatally

postnatal growth retardation ( J:192212 )

• severe

• mice lack a second growth peak postnatally

nervous system

small pituitary gland ( J:192212 )

increased brain weight ( J:192212 )

adipose tissue

decreased subcutaneous adipose tissue amount ( J:192212 )

• at P14

decreased gonadal fat pad weight ( J:192212 )

integument

decreased subcutaneous adipose tissue amount ( J:192212 )

• at P14

liver/biliary system

decreased liver weight ( J:192212 )

endocrine/exocrine glands

small pituitary gland ( J:192212 )