skeleton
• endochondral ossification stopped at the hypertrophic stage
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Allele Symbol Allele Name Allele ID |
Sp7tm1Rnis targeted mutation 1, Riko Nishimura MGI:5466595 |
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Summary |
3 genotypes
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• endochondral ossification stopped at the hypertrophic stage
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• mice exhibit reduced vascular invasion into cartilage because of insufficient space in non-degraded cartilage tissues indicating disruption in cartilage matric degradation compared to in control mice
• however, mice exhibit normal angiogenesis in the bone collar and apoptosis in hypertrophic chondrocytes
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• endochondral ossification stopped at the hypertrophic stage
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• endochondral ossification stopped at the hypertrophic stage
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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