Phenotypes associated with this allele

• Allele Symbol: Dp(In4)20H
• Allele Name: duplication, inverted Chr 4, Harwell 20
• Allele ID: MGI:5466675
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dp(In4)20H/Dp(In4)20H	involves: 101/H * C3H/HeH * PT	MGI:5466709
ot2	Dp(In4)20H/0	involves: 101/H * C3H/HeH * PT	MGI:5466708

Genotype
MGI:5466709

hm1

• Allelic Composition: Dp(In4)20H/Dp(In4)20H
• Genetic Background: involves: 101/H * C3H/HeH * PT

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality at implantation ( J:192799 )

• examination of pregnant uteri of hemizygous mutant females revealed high preimplantation loss of embryos from matings to hemizygous males (33%) vs. wild-type males (5%)

Genotype
MGI:5466708

ot2

• Allelic Composition: Dp(In4)20H/0
• Genetic Background: involves: 101/H * C3H/HeH * PT

craniofacial

abnormal cranium morphology ( J:192799 )

• mice hemizygous for this duplication exhibit a rounded skull shape

growth/size/body

decreased birth weight ( J:192799 )

• the weight of hemizygous mutant neonates is ~70% that of their wild-type littermates

slow postnatal weight gain ( J:192799 )

• hemizygous mutant mice exhibit growth retardation

integument

darkened coat color ( J:192799 )

• variably present

decreased foot pigmentation ( J:192799 )

• variable presence of low grade white spotting affecting only the feet

mortality/aging

lethality at weaning, incomplete penetrance ( J:192799 )

• only ~80% of hemizygous mutant mice survive to weaning

pigmentation

darkened coat color ( J:192799 )

• variably present

decreased foot pigmentation ( J:192799 )

• variable presence of low grade white spotting affecting only the feet

skeleton

abnormal cranium morphology ( J:192799 )

• mice hemizygous for this duplication exhibit a rounded skull shape