Phenotypes associated with this allele

• Allele Symbol: Bmyc^tm1Mpo
• Allele Name: targeted mutation 1, Matti Poutanen
• Allele ID: MGI:5466677
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Bmyc^tm1Mpo/Bmyc^tm1Mpo	involves: 129S7/SvEvBrd * C57BL/6N	MGI:5466678

Genotype
MGI:5466678

hm1

• Allelic Composition: Bmyc^tm1Mpo/Bmyc^tm1Mpo
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality, incomplete penetrance ( J:191587 )

• fewer than expected mice are produced from mating heterozygous mice

reproductive system

reproductive system phenotype ( J:191587 )

N • mice are fertile

increased male germ cell apoptosis ( J:191587 )

♂ • increased apoptosis of spermatogenic cells results in a tendency for a lower sperm concentration

seminiferous tubule degeneration ( J:191587 )

♂ • atrophied in 2 of 37 mice

decreased testis weight ( J:191587 )

♂

small caput epididymis ( J:191587 )

♂ • smaller diameter in segment 3

♂ • however, segment 4 diameter is normal

decreased epididymis weight ( J:191587 )

♂

homeostasis/metabolism

increased circulating luteinizing hormone level ( J:191587 )

♂ • at 3 months

abnormal testosterone level ( J:191587 )

♂ • lower testosterone production per testis

♂ • however, circulating testosterone levels are normal

growth/size/body

decreased body weight ( J:191587 )

♂ • at 2 to 3 weeks of age in male mice

neoplasm

neoplasm ( J:191587 )

♂N • no tumor induction is observed in crosses with Gpx5-Tag2 mice

cellular

increased male germ cell apoptosis ( J:191587 )

♂ • increased apoptosis of spermatogenic cells results in a tendency for a lower sperm concentration

endocrine/exocrine glands

seminiferous tubule degeneration ( J:191587 )

♂ • atrophied in 2 of 37 mice

decreased testis weight ( J:191587 )

♂