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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Trim50tm1Hta
targeted mutation 1, Hiroshi Takeshima
MGI:5466680
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Trim50tm1Hta/Trim50tm1Hta involves: 129S4/SvJae * C57BL/6J MGI:5466682


Genotype
MGI:5466682
hm1
Allelic
Composition		 Trim50tm1Hta/Trim50tm1Hta
Genetic
Background		 involves: 129S4/SvJae * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trim50tm1Hta mutation (0 available); any Trim50 mutation (23 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Abnormal ultrastructural features in Trim50tm1Hta parietal cells

digestive/alimentary system
abnormal gastric parietal cell morphology ( J:191586 )
• deranged canaliculi, swollen microvilli, and accumulated multilamellar membrane complexes after histamine stimulation
hypochlorhydria ( J:191586 )
• reduced acid in gastric secretion
• however, resting phase parietal cells exhibit normal hydrogen/potassium ATPase
increased stomach pH ( J:191586 )
• in fasted mice

endocrine/exocrine glands
abnormal gastric parietal cell morphology ( J:191586 )
• deranged canaliculi, swollen microvilli, and accumulated multilamellar membrane complexes after histamine stimulation




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory