Phenotypes associated with this allele

• Allele Symbol: Cd300lf^tm1Toki
• Allele Name: targeted mutation 1, Toshio Kitamura
• Allele ID: MGI:5467158
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cd300lf^tm1Toki/Cd300lf^tm1Toki	Not Specified	MGI:5467220

Genotype
MGI:5467220

hm1

• Allelic Composition: Cd300lf^tm1Toki/Cd300lf^tm1Toki
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:190979 )

N • normal myeloid and lymphoid development

N • degranulation of IgE sensitized bone marrow mast cells after specific antigen stimulation is normal

abnormal mast cell physiology ( J:190979 )

• cytokine production and cellular protein tyrosine phosphorylation unaffected by specific antigen stimulation

increased susceptibility to type I hypersensitivity reaction ( J:190979 )

• greater and more prolonged drop in body temperature after challenge of sensitized mice with DNP conjugated human serum albumin

• higher plasma histidine levels 3 minutes after antigen challenge

• increased passive anaphylaxis

• increased ear swelling in atopic dermatitis using dust mite extract as an antigen

abnormal interleukin secretion ( J:190979 )

increased interleukin-13 secretion ( J:190979 )

increased interleukin-4 secretion ( J:190979 )

increased interleukin-5 secretion ( J:190979 )

respiratory system inflammation ( J:190979 )

• ova induced chronic airway inflammation is considerably higher than in controls

• increased inflammatory cell accumulation in bronchoalveolar fluid

• increased secretion of IL-4, IL-5, IL-13

respiratory system

respiratory system inflammation ( J:190979 )

• ova induced chronic airway inflammation is considerably higher than in controls

• increased inflammatory cell accumulation in bronchoalveolar fluid

• increased secretion of IL-4, IL-5, IL-13

hematopoietic system

abnormal mast cell physiology ( J:190979 )

• cytokine production and cellular protein tyrosine phosphorylation unaffected by specific antigen stimulation