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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Peli1tm1.1Arte
targeted mutation 1.1, TaconicArtemis
MGI:5467250
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Peli1tm1.1Arte/Peli1tm1.1Arte involves: C57BL/6N MGI:5467260


Genotype
MGI:5467260
hm1
Allelic
Composition		 Peli1tm1.1Arte/Peli1tm1.1Arte
Genetic
Background		 involves: C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Peli1tm1.1Arte mutation (0 available); any Peli1 mutation (31 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Enhanced lymphoid cell infiltration in Peli1tm1.1Arte/Peli1tm1.1Arte tissues

mortality/aging
lethality, incomplete penetrance ( J:191578 )
• fewer than expected mice are produced from heterozygous mice

immune system
immune system phenotype ( J:191578 )
N
• spleen size is normal
enlarged lymph nodes ( J:191578 )
• after 6 months
abnormal peripheral lymph node morphology ( J:191578 )
• enlarged mandibular lymph nodes at 6 months
lymphoid hyperplasia ( J:191578 )
• mild to moderately increase in the amounts of lymphoid tissue around the airways of the lung, the pelvis and blood vessels in the kidney
decreased interferon-alpha secretion ( J:191578 )
• from pIpC-treated bone marrow-derived dendritic cells
decreased interferon-beta secretion ( J:191578 )
• from pIpC- or LPS-treated bone marrow-derived dendritic cells
• from mouse embryonic fibroblasts infected with Sendai virus
decreased interleukin-10 secretion ( J:191578 )
• from pIpC-treated bone marrow-derived dendritic cells
decreased interleukin-12 secretion ( J:191578 )
• from pIpC- or LPS-treated bone marrow-derived dendritic cells
decreased interleukin-6 secretion ( J:191578 )
• from LPS-treated bone marrow-derived dendritic cells
decreased tumor necrosis factor secretion ( J:191578 )
• from pIpC- or LPS-treated bone marrow-derived dendritic cells

digestive/alimentary system
abnormal salivary gland morphology ( J:191578 )
• moderate to marked periductular infiltrates of lymphoid cells in salivary glands

endocrine/exocrine glands
abnormal salivary gland morphology ( J:191578 )
• moderate to marked periductular infiltrates of lymphoid cells in salivary glands




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory