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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Atf5tm1Mrgr
targeted mutation 1, Michael R Green
MGI:5467393
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Atf5tm1Mrgr/Atf5tm1Mrgr involves: C57BL/6 MGI:5467397


Genotype
MGI:5467397
hm1
Allelic
Composition
Atf5tm1Mrgr/Atf5tm1Mrgr
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atf5tm1Mrgr mutation (0 available); any Atf5 mutation (21 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Absence of milk spot in Atf5tm1Mrgr/Atf5tm1Mrgr neonates

mortality/aging
• mice that fail to thrive die between P0 and P6
• 11 of 14 mice die within the first 48 hours after birth
• mice that fail to thrive die between P0 and P6
• 11 of 14 mice die within the first 48 hours after birth

taste/olfaction
• contains a large number of apoptotic cells
• however, cell proliferation is normal
• loss of olfactory marker protein (Omp) staining indicates a dramatic loss of mature olfactory sensory neurons

growth/size/body
• contains a large number of apoptotic cells
• however, cell proliferation is normal
• loss of olfactory marker protein (Omp) staining indicates a dramatic loss of mature olfactory sensory neurons
• in surviving mice throughout 10 weeks after birth

behavior/neurological

nervous system
• loss of olfactory marker protein (Omp) staining indicates a dramatic loss of mature olfactory sensory neurons

craniofacial
• contains a large number of apoptotic cells
• however, cell proliferation is normal
• loss of olfactory marker protein (Omp) staining indicates a dramatic loss of mature olfactory sensory neurons

respiratory system
• contains a large number of apoptotic cells
• however, cell proliferation is normal
• loss of olfactory marker protein (Omp) staining indicates a dramatic loss of mature olfactory sensory neurons





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory