Phenotypes associated with this allele

• Allele Symbol: Rdh13^tm1Xuxn
• Allele Name: targeted mutation 1, Xun Xu
• Allele ID: MGI:5467544
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rdh13^tm1Xuxn/Rdh13^tm1Xuxn	129.Cg-Rdh13^tm1Xuxn	MGI:5467549

Genotype
MGI:5467549

hm1

• Allelic Composition: Rdh13^tm1Xuxn/Rdh13^tm1Xuxn
• Genetic Background: 129.Cg-Rdh13^tm1Xuxn

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

thin retina outer nuclear layer ( J:191615 )

• following exposure to intense light

retina outer nuclear layer degeneration ( J:191615 )

• following exposure to intense light

abnormal retina photoreceptor layer morphology ( J:191615 )

• disintegration of the outer-plus-inner-segment following exposure to intense light

abnormal photoreceptor inner segment morphology ( J:191615 )

• following exposure to intense light, mitochondria in the photoreceptor inner segments are swollen and contain disrupted cristae unlike in wild-type mice

abnormal rod electrophysiology ( J:191615 )

• following exposure to intense light, mice exhibit reduced amplitudes of a- and b-waves under scotopic conditions compared with wild-type mice

homeostasis/metabolism

increased susceptibility to injury ( J:191615 )

• following exposure to intense light, mice exhibit increased disintegration of the outer-plus-inner-segment and outer nuclear layers around the central area where the light of strongest intensity penetrates and exhibit reduced amplitudes of a- and b-waves under scotopic conditions unlike wild-type mice

nervous system

abnormal photoreceptor inner segment morphology ( J:191615 )

• following exposure to intense light, mitochondria in the photoreceptor inner segments are swollen and contain disrupted cristae unlike in wild-type mice