Phenotypes associated with this allele

• Allele Symbol: Atxn2^tm2.1Aub
• Allele Name: targeted mutation 2.1, Georg Auburger
• Allele ID: MGI:5467982
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Atxn2^tm2.1Aub/Atxn2^tm2.1Aub	B6.129S2-Atxn2^tm2.1Aub	MGI:5467984

Genotype
MGI:5467984

hm1

• Allelic Composition: Atxn2^tm2.1Aub/Atxn2^tm2.1Aub
• Genetic Background: B6.129S2-Atxn2^tm2.1Aub

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:188118 )

N • mice exhibit normal grip strength, horizontal/vertical activity, total distance, movement time, number of movements, number of stereotypy counts, margin/center distance nor margin/center time

impaired coordination ( J:188118 )

• 1.2-fold increase in latency to fall from a rotarod at 6 weeks

• decreased latency to fall from a rotarod at 18 months

• however, there is no difference at 3, 6 and 12 months

growth/size/body

decreased body weight ( J:188118 )

• from P20 onward

nervous system

abnormal Purkinje cell morphology ( J:188118 )

• Atxn2 and Pabpc1 protein aggregates in Purkinje cells

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
spinocerebellar ataxia type 2		DOID:0050955	OMIM:183090	J:188118