Phenotypes associated with this allele

• Allele Symbol: Rps6ka5^tm1.1Arte
• Allele Name: targeted mutation 1.1, TaconicArtemis
• Allele ID: MGI:5467986
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rps6ka5^tm1.1Arte/Rps6ka5^tm1.1Arte	involves: C57BL/6	MGI:5467993

Genotype
MGI:5467993

hm1

• Allelic Composition: Rps6ka5^tm1.1Arte/Rps6ka5^tm1.1Arte
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal dendritic spine morphology ( J:188104 )

• mice exhibit an increase in basal spine density and overall spine volume compared with wild-type mice

• mice exposed to environmental enrichment exhibit a blunted increase in dendritic spine density compared with wild-type mice

abnormal miniature excitatory postsynaptic currents ( J:188104 )

• mice exhibit larger miniature excitatory postsynaptic current (mEPSC) amplitude and frequency compared with wild-type mice

• mice exposed to environmental enrichment fail to exhibit an increase in mEPSC amplitude distribution and mean amplitude unlike wild-type mice

• hippocampal neurons treated with TTX fail to exhibit a change in the distribution of mEPSC amplitude or mean amplitude of mEPSCs unlike in wild-type mice

• however, reintroduction of wild-type protein rescues mEPSC amplitude and frequency