Phenotypes associated with this allele

• Allele Symbol: Rbm4^tm1Wtarn
• Allele Name: targeted mutation 1, Woan-Yuh Tarn
• Allele ID: MGI:5467987
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rbm4^tm1Wtarn/Rbm4^tm1Wtarn	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:5467989

Genotype
MGI:5467989

hm1

• Allelic Composition: Rbm4^tm1Wtarn/Rbm4^tm1Wtarn
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

small pancreatic islets ( J:192831 )

• significantly reduced in size

abnormal endocrine pancreas physiology ( J:192831 )

• decrease in islet levels of insulin and glucagon

homeostasis/metabolism

abnormal glucose homeostasis ( J:192831 )

♂ • in males, insulin sensitivity is similar to controls but blood glucose levels recover more slowly in the later stages of an insulin tolerance test

hyperglycemia ( J:192831 )

♂ • in males after an 8 hour fast

decreased circulating insulin level ( J:192831 )

♂ • in fasting males

impaired glucose tolerance ( J:192831 )

♂ • fasting males have an inefficient insulin response to glucose challenge

♂ • in fasting males blood glucose levels are 1.5- to 1.7-fold higher than those of controls after glucose feeding

growth/size/body

decreased body weight ( J:192831 )

• weigh about 10% less than littermates at 8 weeks of age