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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
FanceTg(Tyr)2364E-2a2Ove
transgene insertion 2364E-2a2, Paul Overbeek
MGI:5467996
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
FanceTg(Tyr)2364E-2a2Ove/FanceTg(Tyr)2364E-2a2Ove FVB/N-FanceTg(Tyr)2364E-2a2Ove/Mmjax MGI:6359451


Genotype
MGI:6359451
hm1
Allelic
Composition
FanceTg(Tyr)2364E-2a2Ove/FanceTg(Tyr)2364E-2a2Ove
Genetic
Background
FVB/N-FanceTg(Tyr)2364E-2a2Ove/Mmjax
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
FanceTg(Tyr)2364E-2a2Ove mutation (1 available); any Fance mutation (21 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• very few spermatocytes in tubules at age 3 weeks
• most tubules devoid of spermatocytes at age 4 weeks
• very few mature sperm in tubules at age 8 weeks
• fewer meiotic cells in 20-day old testes

endocrine/exocrine glands
• many tubules show extensive vacuolization between age 3 and 8 weeks

growth/size/body
• 10-15% lower body weight up to age 2 months

reproductive system
• very few spermatocytes in tubules at age 3 weeks
• most tubules devoid of spermatocytes at age 4 weeks
• very few mature sperm in tubules at age 8 weeks
• fewer meiotic cells in 20-day old testes
• many tubules show extensive vacuolization between age 3 and 8 weeks
• 3 out of 8 mice did not produce offspring
• reduced average number of litters sired
• reduced average litter size





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/19/2024
MGI 6.24
The Jackson Laboratory