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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Jak3M1Pgrs
mutation 1, Philippe Gros
MGI:5468008
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Jak3M1Pgrs/Jak3M1Pgrs involves: C57BL/6J * C57BL/10J MGI:5468015
ht2
 		Jak3M1Pgrs/Jak3+ involves: C57BL/6J * C57BL/10J MGI:5468016
ht3
 		Jak3M1Pgrs/Jak3tm1Ljb involves: 129S4/SvJae * C57BL/6J * C57BL/10J MGI:5468017


Genotype
MGI:5468015
hm1
Allelic
Composition		 Jak3M1Pgrs/Jak3M1Pgrs
Genetic
Background		 involves: C57BL/6J * C57BL/10J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Jak3M1Pgrs mutation (0 available); any Jak3 mutation (84 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
increased susceptibility to bacterial infection induced morbidity/mortality ( J:185217 )
• in mice infected with Mycobacteria tuberculosis H37Rv or Citrobacter rodentium compared with C57BL/6J wild-type mice
decreased susceptibility to parasitic infection induced morbidity/mortality ( J:185217 )
• following infection with Plasmodium berghei ANKA-parasitized red blood cells to induce cerebral malaria, mice exhibit longer survival compared with C57BL/6J wild-type mice
• however, splenocytes from infected C57BL/10J restores susceptibility

immune system
enlarged spleen ( J:185217 )
• in mice infected with Mycobacterium bovis BCG
decreased B cell number ( J:185217 )
• in the spleen
absent B cells ( J:185217 )
• complete absence of CD19+ B cells in the bone marrow
decreased NK cell number ( J:185217 )
• in the spleen
increased CD8-positive, alpha-beta T cell number ( J:185217 )
• severe in the thymus and spleen
decreased interferon-gamma secretion ( J:185217 )
• from total spleen cells in response to activation along the Th1 pathway
increased susceptibility to bacterial infection ( J:185217 )
• mice infected with Mycobacterium bovis BCG exhibit splenomegaly and increased spleen bacterial count compared with C57BL/6J wild-type mice
increased susceptibility to bacterial infection induced morbidity/mortality ( J:185217 )
• in mice infected with Mycobacteria tuberculosis H37Rv or Citrobacter rodentium compared with C57BL/6J wild-type mice
decreased susceptibility to parasitic infection induced morbidity/mortality ( J:185217 )
• following infection with Plasmodium berghei ANKA-parasitized red blood cells to induce cerebral malaria, mice exhibit longer survival compared with C57BL/6J wild-type mice
• however, splenocytes from infected C57BL/10J restores susceptibility

hematopoietic system
enlarged spleen ( J:185217 )
• in mice infected with Mycobacterium bovis BCG
decreased B cell number ( J:185217 )
• in the spleen
absent B cells ( J:185217 )
• complete absence of CD19+ B cells in the bone marrow
decreased NK cell number ( J:185217 )
• in the spleen
increased CD8-positive, alpha-beta T cell number ( J:185217 )
• severe in the thymus and spleen

endocrine/exocrine glands

growth/size/body
enlarged spleen ( J:185217 )
• in mice infected with Mycobacterium bovis BCG




Genotype
MGI:5468016
ht2
Allelic
Composition		 Jak3M1Pgrs/Jak3+
Genetic
Background		 involves: C57BL/6J * C57BL/10J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Jak3M1Pgrs mutation (0 available); any Jak3 mutation (84 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
decreased susceptibility to parasitic infection induced morbidity/mortality ( J:185217 )
• half of mice are resistant lethality associated with cerebral malaria induced by infection with Plasmodium berghei ANKA-parasitized red blood cells compared with control mice mice

immune system
decreased susceptibility to parasitic infection induced morbidity/mortality ( J:185217 )
• half of mice are resistant lethality associated with cerebral malaria induced by infection with Plasmodium berghei ANKA-parasitized red blood cells compared with control mice mice




Genotype
MGI:5468017
ht3
Allelic
Composition		 Jak3M1Pgrs/Jak3tm1Ljb
Genetic
Background		 involves: 129S4/SvJae * C57BL/6J * C57BL/10J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Jak3M1Pgrs mutation (0 available); any Jak3 mutation (84 available)
Jak3tm1Ljb mutation (1 available); any Jak3 mutation (84 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
decreased susceptibility to parasitic infection induced morbidity/mortality ( J:185217 )
• mice are resistant lethality associated with cerebral malaria induced by infection with Plasmodium berghei ANKA-parasitized red blood cells compared with C57BL/10J mice

immune system
decreased susceptibility to parasitic infection induced morbidity/mortality ( J:185217 )
• mice are resistant lethality associated with cerebral malaria induced by infection with Plasmodium berghei ANKA-parasitized red blood cells compared with C57BL/10J mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory