Phenotypes associated with this allele

• Allele Symbol: Cd247^tm2.1Lov
• Allele Name: targeted mutation 2.1, Paul E Love
• Allele ID: MGI:5468025
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cd247^tm2.1Lov/Cd247^tm2.1Lov	B6.Cg-Cd247^tm2.1Lov	MGI:5468140
hm2	Cd247^tm2.1Lov/Cd247^tm2.1Lov	Not Specified	MGI:5468137
ht3	Cd247^tm1Lov/Cd247^tm2.1Lov	involves: 129S4/SvJae	MGI:5468138
cx4	Cd247^tm2.1Lov/Cd247^tm2.1Lov Tg(TcraH-Y,TcrbH-Y)71Vbo/0	involves: C57BL/6J * DBA/2J	MGI:5468139

Genotype
MGI:5468140

hm1

• Allelic Composition: Cd247^tm2.1Lov/Cd247^tm2.1Lov
• Genetic Background: B6.Cg-Cd247^tm2.1Lov

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased susceptibility to experimental autoimmune encephalomyelitis ( J:192915 )

• consistent but not statistically significant

Genotype
MGI:5468137

hm2

• Allelic Composition: Cd247^tm2.1Lov/Cd247^tm2.1Lov
• Genetic Background: Not Specified

immune system

immune system phenotype ( J:192915 )

N • mice do not develop spontaneous autoimmune disease

decreased thymocyte number ( J:192915 )

abnormal T cell differentiation ( J:192915 )

• depending on the nature of the negative selecting interaction, thymocytes exhibit impaired negative selection compared with control mice

• mice exhibit an increase in regulatory T cell numbers due to increased generation of thymus-derived T regulatory cells

abnormal T-helper 1 cell differentiation ( J:192915 )

• ex vivo and after in vitro stimulation, CD4+ T cells exhibit significant skewing to Th1 compared with control cell

abnormal gamma-delta T cell differentiation ( J:192915 )

• impaired development

decreased CD4-positive, alpha-beta T cell number ( J:192915 )

• in the thymus and periphery

decreased CD8-positive, alpha-beta T cell number ( J:192915 )

• in the thymus and periphery

increased regulatory T cell number ( J:192915 )

• in the thymus, lymph nodes and spleen due to increased generation of thymus-derived T regulatory cells

abnormal NK T cell morphology ( J:192915 )

• impaired development

abnormal T cell physiology ( J:192915 )

• mice exhibit increased T cells with memory-like phenotype that proliferate in vivo compared with control mice

• regulatory T cells exhibit enhanced suppressive activity to suppress the proliferation of effector T cells

decreased thymocyte apoptosis ( J:192915 )

• double-positive thymocytes are resistant to anti-CD3 and anti-CD28-induced apoptosis compared with control cells

abnormal regulatory T cell physiology ( J:192915 )

• in the thymus, lymph nodes and spleen due to increased generation of thymus-derived T regulatory cells

cellular

decreased thymocyte apoptosis ( J:192915 )

• double-positive thymocytes are resistant to anti-CD3 and anti-CD28-induced apoptosis compared with control cells

hematopoietic system

decreased thymocyte number ( J:192915 )

abnormal T cell differentiation ( J:192915 )

• depending on the nature of the negative selecting interaction, thymocytes exhibit impaired negative selection compared with control mice

• mice exhibit an increase in regulatory T cell numbers due to increased generation of thymus-derived T regulatory cells

abnormal T-helper 1 cell differentiation ( J:192915 )

• ex vivo and after in vitro stimulation, CD4+ T cells exhibit significant skewing to Th1 compared with control cell

abnormal gamma-delta T cell differentiation ( J:192915 )

• impaired development

decreased CD4-positive, alpha-beta T cell number ( J:192915 )

• in the thymus and periphery

decreased CD8-positive, alpha-beta T cell number ( J:192915 )

• in the thymus and periphery

increased regulatory T cell number ( J:192915 )

• in the thymus, lymph nodes and spleen due to increased generation of thymus-derived T regulatory cells

abnormal NK T cell morphology ( J:192915 )

• impaired development

abnormal T cell physiology ( J:192915 )

• mice exhibit increased T cells with memory-like phenotype that proliferate in vivo compared with control mice

• regulatory T cells exhibit enhanced suppressive activity to suppress the proliferation of effector T cells

decreased thymocyte apoptosis ( J:192915 )

• double-positive thymocytes are resistant to anti-CD3 and anti-CD28-induced apoptosis compared with control cells

abnormal regulatory T cell physiology ( J:192915 )

• in the thymus, lymph nodes and spleen due to increased generation of thymus-derived T regulatory cells

abnormal bone marrow cell physiology ( J:192915 )

• bone marrow cells transplanted into Rag1 null mice induce autoimmune disorder with increased incidence of inflammatory lesions and anti-nuclear antibodies compared when control bone marrow cells are transplanted

• however, mice do not develop spontaneous autoimmune disease

endocrine/exocrine glands

decreased thymocyte apoptosis ( J:192915 )

• double-positive thymocytes are resistant to anti-CD3 and anti-CD28-induced apoptosis compared with control cells

decreased thymocyte number ( J:192915 )

Genotype
MGI:5468138

ht3

• Allelic Composition: Cd247^tm1Lov/Cd247^tm2.1Lov
• Genetic Background: involves: 129S4/SvJae

immune system

immune system phenotype ( J:192915 )

N • mice do not develop spontaneous autoimmune disease

Genotype
MGI:5468139

cx4

• Allelic Composition: Cd247^tm2.1Lov/Cd247^tm2.1Lov; Tg(TcraH-Y,TcrbH-Y)71Vbo/0
• Genetic Background: involves: C57BL/6J * DBA/2J

hematopoietic system

abnormal T cell differentiation ( J:192915 )

• thymocyte negative selection in response to ubiquitous male antigen is impaired, but not abrogated, compared to in control mice

immune system

abnormal T cell differentiation ( J:192915 )

• thymocyte negative selection in response to ubiquitous male antigen is impaired, but not abrogated, compared to in control mice