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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gfi1tm5.1(GFI1*)Tmo
targeted mutation 5.1, Tarik Moroy
MGI:5468263
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Gfi1tm5.1(GFI1*)Tmo/Gfi1tm5.1(GFI1*)Tmo involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:5468267
ht2
 		Gfi1tm5.1(GFI1*)Tmo/Gfi1+ involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:5468272
cn3
 		Gfi1tm5.1(GFI1*)Tmo/Gfi1tm5.1(GFI1*)Tmo
Krastm4Tyj/Kras+
Tg(Mx1-cre)1Cgn/0 		involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * CBA MGI:5468269
cn4
 		Gfi1tm5.1(GFI1*)Tmo/Gfi1+
Krastm4Tyj/Kras+
Tg(Mx1-cre)1Cgn/0 		involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * CBA MGI:5468270


Genotype
MGI:5468267
hm1
Allelic
Composition		 Gfi1tm5.1(GFI1*)Tmo/Gfi1tm5.1(GFI1*)Tmo
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gfi1tm5.1(GFI1*)Tmo mutation (0 available); any Gfi1 mutation (31 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
hematopoietic system phenotype ( J:192927 )
N
• mice exhibit normal lymphoid differentiation in the bone marrow, spleen and thymus and normal numbers of hematopoietic stem cells
abnormal definitive hematopoiesis ( J:192927 )
• increased granulomonocytic progenitors with a higher proportion in S/G2/M phase
increased monocyte cell number ( J:192927 )
• with a tendency towards lower numbers of granulocytes

cellular
abnormal mitosis ( J:192927 )
• a higher proportion of granulomonocytic progenitors are undergoing cell cycling compared with wild-type mice or Gfi1tm6.1(GFI1)Tmo homozygotes

immune system
increased monocyte cell number ( J:192927 )
• with a tendency towards lower numbers of granulocytes




Genotype
MGI:5468272
ht2
Allelic
Composition		 Gfi1tm5.1(GFI1*)Tmo/Gfi1+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gfi1tm5.1(GFI1*)Tmo mutation (0 available); any Gfi1 mutation (31 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal definitive hematopoiesis ( J:192927 )
• proliferative expansion of granulomonocytic progenitors

cellular
abnormal mitosis ( J:192927 )
• proliferative expansion of granulomonocytic progenitors




Genotype
MGI:5468269
cn3
Allelic
Composition		 Gfi1tm5.1(GFI1*)Tmo/Gfi1tm5.1(GFI1*)Tmo
Krastm4Tyj/Kras+
Tg(Mx1-cre)1Cgn/0
Genetic
Background		 involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gfi1tm5.1(GFI1*)Tmo mutation (0 available); any Gfi1 mutation (31 available)
Krastm4Tyj mutation (9 available); any Kras mutation (84 available)
Tg(Mx1-cre)1Cgn mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:192927 )
• of all pIpC-treated mice faster than control mice

hematopoietic system
myeloid hyperplasia ( J:192927 )
• all pIpC-treated mice die of myeloproliferative disorder accompanied by an expansion of myeloid cells in the bone marrow, an infiltration of myeloid cells in the spleen, and the appearance of blast cells in the blood faster than control mice

immune system
myeloid hyperplasia ( J:192927 )
• all pIpC-treated mice die of myeloproliferative disorder accompanied by an expansion of myeloid cells in the bone marrow, an infiltration of myeloid cells in the spleen, and the appearance of blast cells in the blood faster than control mice




Genotype
MGI:5468270
cn4
Allelic
Composition		 Gfi1tm5.1(GFI1*)Tmo/Gfi1+
Krastm4Tyj/Kras+
Tg(Mx1-cre)1Cgn/0
Genetic
Background		 involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gfi1tm5.1(GFI1*)Tmo mutation (0 available); any Gfi1 mutation (31 available)
Krastm4Tyj mutation (9 available); any Kras mutation (84 available)
Tg(Mx1-cre)1Cgn mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:192927 )
• of all pIpC-treated mice faster than control mice

hematopoietic system
myeloid hyperplasia ( J:192927 )
• all pIpC-treated mice die of myeloproliferative disorder accompanied by an expansion of myeloid cells in the bone marrow, an infiltration of myeloid cells in the spleen, and the appearance of blast cells in the blood faster than control mice

immune system
myeloid hyperplasia ( J:192927 )
• all pIpC-treated mice die of myeloproliferative disorder accompanied by an expansion of myeloid cells in the bone marrow, an infiltration of myeloid cells in the spleen, and the appearance of blast cells in the blood faster than control mice




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory