Phenotypes associated with this allele

• Allele Symbol: Gfi1^{tm6.1(GFI1)Tmo}
• Allele Name: targeted mutation 6.1, Tarik Moroy
• Allele ID: MGI:5468264
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gfi1^tm6.1(GFI1)Tmo/Gfi1^tm6.1(GFI1)Tmo	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:5468273
cn2	Gfi1^tm6.1(GFI1)Tmo/Gfi1^tm6.1(GFI1)Tmo Kras^tm4Tyj/Kras^+ Tg(Mx1-cre)1Cgn/0	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * CBA	MGI:5468271

Genotype
MGI:5468273

hm1

• Allelic Composition: Gfi1^{tm6.1(GFI1)Tmo}/Gfi1^{tm6.1(GFI1)Tmo}
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

hematopoietic system phenotype ( J:192927 )

N • mice exhibit normal lymphoid differentiation in the bone marrow, spleen and thymus and normal numbers of hematopoietic stem cells

Genotype
MGI:5468271

cn2

• Allelic Composition: Gfi1^{tm6.1(GFI1)Tmo}/Gfi1^{tm6.1(GFI1)Tmo}; Kras^tm4Tyj/Kras⁺; Tg(Mx1-cre)1Cgn/0
• Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * CBA

mortality/aging

premature death ( J:192927 )

• of all pIpC-treated mice

hematopoietic system

myeloid hyperplasia ( J:192927 )

• all pIpC-treated mice die of myeloproliferative disorder accompanied by an expansion of myeloid cells in the bone marrow, an infiltration of myeloid cells in the spleen, and the appearance of blast cells in the blood faster

immune system

myeloid hyperplasia ( J:192927 )

• all pIpC-treated mice die of myeloproliferative disorder accompanied by an expansion of myeloid cells in the bone marrow, an infiltration of myeloid cells in the spleen, and the appearance of blast cells in the blood faster