Phenotypes associated with this allele

• Allele Symbol: Ccnd1^tm5.1Pisc
• Allele Name: targeted mutation 5.1, Piotr Sicinski
• Allele ID: MGI:5468336
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ccnd1^tm5.1Pisc/Ccnd1^tm5.1Pisc	Not Specified	MGI:5468348
ht2	Ccnd1^tm1Wbg/Ccnd1^tm5.1Pisc	involves: 129S2/SvPas	MGI:5468349
cn3	Ccnd1^tm1Wbg/Ccnd1^tm5.1Pisc Tg(CAG-cre/Esr1*)5Amc/0	involves: 129S2/SvPas * C57BL/6 * CBA	MGI:5468350
cn4	Ccnd1^tm1Wbg/Ccnd1^tm5.1Pisc Tg(CAG-cre/Esr1*)5Amc/0 Tg(MMTV-Erbb2)NK1Mul/0	involves: 129S2/SvPas * C57BL/6 * CBA * FVB/N	MGI:5468352

Genotype
MGI:5468348

hm1

• Allelic Composition: Ccnd1^tm5.1Pisc/Ccnd1^tm5.1Pisc
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

normal phenotype

no abnormal phenotype detected ( J:192032 )

• mice develop normally and display no phenotypic abnormalities

Genotype
MGI:5468349

ht2

• Allelic Composition: Ccnd1^tm1Wbg/Ccnd1^tm5.1Pisc
• Genetic Background: involves: 129S2/SvPas

normal phenotype

no abnormal phenotype detected ( J:192032 )

• mice are phenotypically normal

Genotype
MGI:5468350

cn3

• Allelic Composition: Ccnd1^tm1Wbg/Ccnd1^tm5.1Pisc; Tg(CAG-cre/Esr1*)5Amc/0
• Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA

normal phenotype

no abnormal phenotype detected ( J:192032 )

• tamoxifen-treated mice exhibit no obvious abnormalities

Genotype
MGI:5468352

cn4

• Allelic Composition: Ccnd1^tm1Wbg/Ccnd1^tm5.1Pisc; Tg(CAG-cre/Esr1*)5Amc/0; Tg(MMTV-Erbb2)NK1Mul/0
• Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA * FVB/N

neoplasm

decreased tumor growth/size ( J:192032 )

• tamoxifen-treatment halts cancer progression and lowers tumor burden with increased senescence of tumor cells compared to in control mice