Phenotypes associated with this allele

• Allele Symbol: Ccnd3^tm2.1Pisc
• Allele Name: targeted mutation 2.1, Piotr Sicinski
• Allele ID: MGI:5468337
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Ccnd3^tm2.1Pisc/Ccnd3^tm2.1Pisc Tg(CAG-cre/Esr1*)5Amc/0	involves: C57BL/6 * CBA	MGI:5468353
cn2	Ccnd3^tm2.1Pisc/Ccnd3^tm2.1Pisc Tg(Mx1-cre)1Cgn/0	involves: C57BL/6 * CBA	MGI:5468354

Genotype
MGI:5468353

cn1

• Allelic Composition: Ccnd3^tm2.1Pisc/Ccnd3^tm2.1Pisc; Tg(CAG-cre/Esr1*)5Amc/0
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

normal phenotype

no abnormal phenotype detected ( J:192032 )

• tamoxifen-treated mice exhibit no obvious abnormalities

Genotype
MGI:5468354

cn2

• Allelic Composition: Ccnd3^tm2.1Pisc/Ccnd3^tm2.1Pisc; Tg(Mx1-cre)1Cgn/0
• Genetic Background: involves: C57BL/6 * CBA

hematopoietic system

abnormal hematopoietic system morphology/development ( J:192032 )

• pIpC-treated mice phenocopy abnormalities observed in Ccnd3^tm1Pisc homozygotes

small thymus ( J:192032 )

• in pIpC-treated mice

decreased erythrocyte cell number ( J:192032 )

• modest in pIpC-treated mice

decreased leukocyte cell number ( J:192032 )

• modest in pIpC-treated mice

decreased double-positive T cell number ( J:192032 )

• in the thymus of pIpC-treated mice

abnormal hematopoietic stem cell physiology ( J:192032 )

• hematopoietic progenitor cells transduced with a retrovirus encoding activated Notch1 and injected into irradiated C57BL/6 mice induce apoptosis in acute lymphoblastic leukemia cells following pIpC-treatment compared with control mice

immune system

small thymus ( J:192032 )

• in pIpC-treated mice

decreased leukocyte cell number ( J:192032 )

• modest in pIpC-treated mice

decreased double-positive T cell number ( J:192032 )

• in the thymus of pIpC-treated mice

endocrine/exocrine glands

small thymus ( J:192032 )

• in pIpC-treated mice