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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Pld1tm1.1Mafr
targeted mutation 1.1, Michael Frohman
MGI:5468471
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Pld1tm1.1Mafr/Pld1tm1.1Mafr B6.Cg-Pld1tm1.1Mafr MGI:5468549
hm2
 		Pld1tm1.1Mafr/Pld1tm1.1Mafr Not Specified MGI:5468551
cx3
 		Pld1tm1.1Mafr/Pld1tm1.1Mafr
Pld2tm1Yaka/Pld2tm1Yaka 		involves: C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj MGI:5468553


Genotype
MGI:5468549
hm1
Allelic
Composition		 Pld1tm1.1Mafr/Pld1tm1.1Mafr
Genetic
Background		 B6.Cg-Pld1tm1.1Mafr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pld1tm1.1Mafr mutation (1 available); any Pld1 mutation (64 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
abnormal tumor vascularization ( J:193451 )
• almost complete absence of small blood vessels in implanted tumors due to impaired tumor angiogenesis
decreased metastatic potential ( J:193451 )
• of implanted melanoma cells
decreased tumor growth/size ( J:193451 )
• of implanted B16F10 mouse melanoma or mouse Lewis lung carcinoma cells with massive macrophage infiltration

cardiovascular system
abnormal tumor vascularization ( J:193451 )
• almost complete absence of small blood vessels in implanted tumors due to impaired tumor angiogenesis
decreased angiogenesis ( J:193451 )
• impaired implanted tumor angiogenesis
• no vascularization of VEGF Matrigel plugs (impaired neoangiogenesis)
• decreased endothelial cell emigration and microvessel formation in aortic rings
• however, lung microvascular endothelial cell proliferation is normal

homeostasis/metabolism
abnormal platelet physiology ( J:193451 )
• activated platelets exhibit reduced binding to implanted tumor cells compared with control mice

hematopoietic system
abnormal platelet physiology ( J:193451 )
• activated platelets exhibit reduced binding to implanted tumor cells compared with control mice




Genotype
MGI:5468551
hm2
Allelic
Composition		 Pld1tm1.1Mafr/Pld1tm1.1Mafr
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pld1tm1.1Mafr mutation (1 available); any Pld1 mutation (64 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:192844 )
• mice are healthy and fertile with normal fMLP-induced neutrophil functions and ethanol inhibition of those induced functions




Genotype
MGI:5468553
cx3
Allelic
Composition		 Pld1tm1.1Mafr/Pld1tm1.1Mafr
Pld2tm1Yaka/Pld2tm1Yaka
Genetic
Background		 involves: C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pld1tm1.1Mafr mutation (1 available); any Pld1 mutation (64 available)
Pld2tm1Yaka mutation (1 available); any Pld2 mutation (49 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:192844 )
• mice are healthy and fertile with normal fMLP-induced neutrophil functions and ethanol inhibition of those induced functions and fMLP-stimulated phosphatidic acid production




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory