immune system
• after immunization
|
• after immunization
|
• NP-specific IgG1 early after immunization with NP-KLH
• NP-specific IgM secreting cells in the spleen and bone marrow after immunization with NP-KLH
• NP-specific IgG1 in the first week after NP-KLH immunization
|
• NP-specific IgG3 early after immunization with NP-Ficoll
|
• NP-specific IgM early after immunization with NP-KLH or NP-Ficoll
• NP-specific IgM secreting cells in the spleen and bone marrow after immunization with NP-KLH
|
• in a collagen-induced arthritis model, mice develop arthritic sooner and with greater severity compared with wild-type mice
|
• after secondary immunization with NP-KLH
• spontaneously after 14 months
|
• 8, but not 11, days after NP-KLH immunization
• after secondary immunization with NP-KLH
• spontaneously after 14 months
|
skeleton
• in a collagen-induced arthritis model, mice develop arthritic sooner and with greater severity compared with wild-type mice
|
renal/urinary system
|
• female mice spontaneously develop pronounced glomerular immune complex deposition unlike wild-type mice
• however, kidney function is normal
|
cellular
• after immunization
|
hematopoietic system
• after immunization
|
• after immunization
|
• NP-specific IgG1 early after immunization with NP-KLH
• NP-specific IgM secreting cells in the spleen and bone marrow after immunization with NP-KLH
• NP-specific IgG1 in the first week after NP-KLH immunization
|
• NP-specific IgG3 early after immunization with NP-Ficoll
|
• NP-specific IgM early after immunization with NP-KLH or NP-Ficoll
• NP-specific IgM secreting cells in the spleen and bone marrow after immunization with NP-KLH
|