Allele Symbol Allele Name Allele ID |
Sh3gl2tm1Pdc targeted mutation 1, Pietro De Camilli MGI:5468726 |
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Summary |
5 genotypes
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• some mice die within 24 hours of birth
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• mossy fiber terminals exhibit reduced numbers of synaptic vesicles and increased clathrin-coated vesicles compared with wild-type mice
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• climbing fibers are thicker and shorter than in wild-type mice
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• synapses accumulate clathrin-coated vesicles but not clathrin-coated pits
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• reduced number
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• endocytic recovery of synaptic vesicle is 2.5-fold slower than in controls
• however, this defect is rescued by re-expression of Sh3gl1
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• reduction in peak amplitude in response to a single stimulus
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• more than 2.5 times reduction in the frequency and decreased amplitude
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• after a 30 AP at 10, but not 1, Hz stimulus
• recovering is delayed
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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