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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cxcl12tm1.1Link
targeted mutation 1.1, Daniel C Link
MGI:5468835
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Cxcl12tm1Tng/Cxcl12tm1.1Link
Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0 		involves: 129P2/OlaHsd * C57BL/6 * CD-1 * FVB/N MGI:5468941
cn2
 		Cxcl12tm1Tng/Cxcl12tm1.1Link
Tg(Tek-cre)1Ywa/0 		involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL MGI:5468943
cn3
 		Cxcl12tm1Tng/Cxcl12tm1.1Link
Tg(Prrx1-cre)1Cjt/0 		involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL/J MGI:5468942
cn4
 		Cxcl12tm1Tng/Cxcl12tm1.1Link
Tg(BGLAP-cre)1Clem/0 		involves: 129P2/OlaHsd * C57BL/6J * C57BL/6NTac * FVB/N MGI:5468940


Genotype
MGI:5468941
cn1
Allelic
Composition		 Cxcl12tm1Tng/Cxcl12tm1.1Link
Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * CD-1 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cxcl12tm1.1Link mutation (1 available); any Cxcl12 mutation (25 available)
Cxcl12tm1Tng mutation (1 available); any Cxcl12 mutation (25 available)
Tg(Sp7-tTA,tetO-EGFP/cre)1Amc mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal blood cell morphology/development ( J:193594 )
• the numbers of colony-forming cells and KSL cells are increased in the blood and spleen, demonstrating constitutive HPC mobilization, compared with control mice
decreased B cell number ( J:193594 )
• in the bone marrow
decreased hematopoietic stem cell number ( J:193594 )
• modest decrease in the absolute number
abnormal hematopoietic stem cell physiology ( J:193594 )
• increased cycling of more mature KSL progenitors in the blood
• however, hematopoietic stem cell cycling is normal

immune system
decreased B cell number ( J:193594 )
• in the bone marrow




Genotype
MGI:5468943
cn2
Allelic
Composition		 Cxcl12tm1Tng/Cxcl12tm1.1Link
Tg(Tek-cre)1Ywa/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cxcl12tm1.1Link mutation (1 available); any Cxcl12 mutation (25 available)
Cxcl12tm1Tng mutation (1 available); any Cxcl12 mutation (25 available)
Tg(Tek-cre)1Ywa mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
hematopoietic system phenotype ( J:193594 )
N
• hematopoietic stem cell numbers and cycling are normal
abnormal bone marrow cell physiology ( J:193594 )
• bone marrow cells exhibit multilineage long-term repopulating defects
• however, self-renewal capacity is restored by transplantation into a wild-type environment




Genotype
MGI:5468942
cn3
Allelic
Composition		 Cxcl12tm1Tng/Cxcl12tm1.1Link
Tg(Prrx1-cre)1Cjt/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cxcl12tm1.1Link mutation (1 available); any Cxcl12 mutation (25 available)
Cxcl12tm1Tng mutation (1 available); any Cxcl12 mutation (25 available)
Tg(Prrx1-cre)1Cjt mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal common lymphocyte progenitor cell morphology ( J:193594 )
• reduced B cell lymphoid progenitors
decreased B cell number ( J:193594 )
• in the bone marrow
abnormal bone marrow cell physiology ( J:193594 )
• bone marrow cells exhibit multilineage long-term repopulating defects
• however, self-renewal capacity is restored by transplantation into a wild-type environment
abnormal hematopoietic stem cell physiology ( J:193594 )
• increased cycling of hematopoietic stem cells and more mature KSL progenitors in the spleen

immune system
decreased B cell number ( J:193594 )
• in the bone marrow




Genotype
MGI:5468940
cn4
Allelic
Composition		 Cxcl12tm1Tng/Cxcl12tm1.1Link
Tg(BGLAP-cre)1Clem/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6J * C57BL/6NTac * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cxcl12tm1.1Link mutation (1 available); any Cxcl12 mutation (25 available)
Cxcl12tm1Tng mutation (1 available); any Cxcl12 mutation (25 available)
Tg(BGLAP-cre)1Clem mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
hematopoietic system phenotype ( J:193594 )
N
• mice exhibit normal hematopoietic stem cell and lymphoid progenitors morphology and physiology
decreased B cell number ( J:193594 )
• in the blood

immune system
decreased B cell number ( J:193594 )
• in the blood




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory