Phenotypes associated with this allele

• Allele Symbol: Casp4^tm1.1Vmd
• Allele Name: targeted mutation 1.1, Vishva M Dixit
• Allele ID: MGI:5468949
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Casp4^tm1.1Vmd/Casp4^tm1.1Vmd	involves: C57BL/6	MGI:5468970

Genotype
MGI:5468970

hm1

• Allelic Composition: Casp4^tm1.1Vmd/Casp4^tm1.1Vmd
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased susceptibility to xenobiotic induced morbidity/mortality ( J:193522 )

• in response to LPS challenge in a model of acute septic shock

immune system

decreased macrophage apoptosis ( J:193522 )

• impaired cell death in response to CTB, E. coli, C. rodentium and V. cholerae

• however, bone marrow-derived macrophages stimulated with ATP of C. difficile toxin B exhibit normal cell death

decreased circulating interleukin-1 alpha level ( J:193522 )

• in response to LPS challenge in a model of acute septic shock

decreased circulating interleukin-1 beta level ( J:193522 )

• in response to LPS challenge in a model of acute septic shock

decreased circulating interleukin-18 level ( J:193522 )

• in response to LPS challenge in a model of acute septic shock

decreased interleukin-1 alpha secretion ( J:193522 )

• from LPS-primed bone marrow-derived macrophage in response to CTB and E. coli

decreased interleukin-1 beta secretion ( J:193522 )

• from LPS-primed bone marrow-derived macrophages in response to cholera toxin B (CTB), E. coli, C. rodentium or V. cholera (with or without LPS priming)

• however, secretion in response to poly(dA:dT) double-stranded DNA, Francisella tularensis, flagellin, Pseudomonas aeruginosa adenylcyclase (AC) toxin14, listeriolysin O (LLO) toxin15, Clostridium difficile toxin B, monosodium urate (MSU), calcium pyrophosphate (CPPD)2,22 or the ionophore nigericin is normal

decreased susceptibility to endotoxin shock ( J:193522 )

• mice are resistant to LPS challenge in a model of acute septic shock with reduced mortality and serum levels of IL1b, IL1a and IL18

cellular

decreased macrophage apoptosis ( J:193522 )

• impaired cell death in response to CTB, E. coli, C. rodentium and V. cholerae

• however, bone marrow-derived macrophages stimulated with ATP of C. difficile toxin B exhibit normal cell death

homeostasis/metabolism

decreased circulating interleukin-1 alpha level ( J:193522 )

• in response to LPS challenge in a model of acute septic shock

decreased circulating interleukin-1 beta level ( J:193522 )

• in response to LPS challenge in a model of acute septic shock

decreased circulating interleukin-18 level ( J:193522 )

• in response to LPS challenge in a model of acute septic shock

decreased susceptibility to xenobiotic induced morbidity/mortality ( J:193522 )

• in response to LPS challenge in a model of acute septic shock

hematopoietic system

decreased macrophage apoptosis ( J:193522 )

• impaired cell death in response to CTB, E. coli, C. rodentium and V. cholerae

• however, bone marrow-derived macrophages stimulated with ATP of C. difficile toxin B exhibit normal cell death