Analysis Tools
immune system
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• impaired cell death in response to ATP and Clostridium difficile toxin B
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• in response to LPS challenge in a model of acute septic shock
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• in response to LPS challenge in a model of acute septic shock
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• from LPS-primed bone marrow-derived macrophage in response to ATP and C. difficile
• however, IL1a secretion is restored in response to CTB and E. coli
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• LPS-primed bone marrow-derived macrophages fail to produce IL1b and IL18 in response to ATP, Clostridium difficile toxin B, cholera toxin B (CTB) or E. coli unlike controls
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• LPS-primed bone marrow-derived macrophages fail to produce IL1b and IL18 in response to ATP, Clostridium difficile toxin B, cholera toxin B (CTB) or E. coli unlike controls
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• mice treated with LPS challenge in a model of acute septic shock exhibit reduced serum levels of IL1b and IL18 compared with controls
• however, mice do not survive beyond 26 hours and serum levels of IL1a are increased
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homeostasis/metabolism
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• in response to LPS challenge in a model of acute septic shock
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• in response to LPS challenge in a model of acute septic shock
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cellular
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• impaired cell death in response to ATP and Clostridium difficile toxin B
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hematopoietic system
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• impaired cell death in response to ATP and Clostridium difficile toxin B
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