Phenotypes associated with this allele

• Allele Symbol: Strn3^{tm1b(KOMP)Wtsi}
• Allele Name: targeted mutation 1b, Wellcome Trust Sanger Institute
• Allele ID: MGI:5468974
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Strn3^tm1b(KOMP)Wtsi/Strn3^tm1b(KOMP)Wtsi	B6N(Cg)-Strn3^tm1b(KOMP)Wtsi/J	MGI:5631594
ht2	Strn3^tm1b(KOMP)Wtsi/Strn3^+	B6N(Cg)-Strn3^tm1b(KOMP)Wtsi/J	MGI:5631593

Genotype
MGI:5631594

hm1

• Allelic Composition: Strn3^{tm1b(KOMP)Wtsi}/Strn3^{tm1b(KOMP)Wtsi}
• Genetic Background: B6N(Cg)-Strn3^{tm1b(KOMP)Wtsi}/J
• Cell Lines: EPD0550_1_B09

Data Sources

IMPC Data for Strn3

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Strn3^{tm1b(KOMP)Wtsi}/Strn3^{tm1b(KOMP)Wtsi} mice exhibit embryonic lethality, with embryos recovered at E7.5 but not at E9.5. Embryos are smaller at E7.5 and while the primitive streak is formed, no other hallmarks of gastrulation are seen at E7.5.

cardiovascular system

hemorrhage ( J:211773 )

IMPC - JAX

embryo

failure to gastrulate ( J:279207 )

• although the primitive streak has formed, no other hallmarks typical of gastrulating embryos are observed at E7.5

embryonic growth arrest ( J:279207 )

• embryos arrest prior to gastrulation

decreased embryo size ( J:279207 )

• embryos appear smaller than controls at E7.5

absent head fold ( J:279207 )

• no head folds are present at E7.5

absent primitive node ( J:279207 )

• no morphological embryonic node is present at E7.5

growth/size/body

decreased embryo size ( J:279207 )

• embryos appear smaller than controls at E7.5

homeostasis/metabolism

edema ( J:211773 )

IMPC - JAX

mortality/aging

preweaning lethality, complete penetrance ( J:211773 )

IMPC - JAX

embryonic lethality between implantation and placentation, complete penetrance ( J:279207 )

• homozygous embryos are recovered at E7.5 (17% versus 25%, n=36) but arrest prior to gastrulation; no homozygous embryos are recovered at E9.5

Genotype
MGI:5631593

ht2

• Allelic Composition: Strn3^{tm1b(KOMP)Wtsi}/Strn3⁺
• Genetic Background: B6N(Cg)-Strn3^{tm1b(KOMP)Wtsi}/J
• Cell Lines: EPD0550_1_B09

Data Sources

IMPC Data for Strn3

behavior/neurological

abnormal behavior ( J:211773 )

♀

IMPC - JAX

decreased thigmotaxis ( J:211773 )

♀

IMPC - JAX

hyperactivity ( J:211773 )

♀

IMPC - JAX

increased vertical activity ( J:211773 )

♂

IMPC - JAX

homeostasis/metabolism

increased fasting circulating glucose level ( J:211773 )

IMPC - JAX

decreased circulating glucose level ( J:211773 )

♂

IMPC - JAX