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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Il2rgtm1.1Asin
targeted mutation 1.1, Alfred Singer
MGI:5469000
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		B2mtm1Unc/B2mtm1Unc
Il2rgtm1.1Asin/Il2rgtm1Wjl
Tg(Cd8a*-cre)B8Asin/0 		involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 MGI:5469014
cn2
 		Il2rgtm1.1Asin/Il2rgtm1Wjl
Tg(Cd8a*-cre)B8Asin/0 		involves: 129S4/SvJae * C57BL/6 MGI:5469012
cn3
 		Il2rgtm1.1Asin/Il2rgtm1Wjl
Tg(Cd8a*-cre)B8Asin/0
Tg(LCKprBCL2)36Sjk/0 		involves: 129S4/SvJae * C57BL/6 MGI:5469013
cn4
 		Il2rgtm1.1Asin/Il2rgtm1Wjl
Tg(Cd4-cre)1Cwi/0 		involves: 129S4/SvJae * C57BL/6 * DBA/2 MGI:5469011


Genotype
MGI:5469014
cn1
Allelic
Composition		 B2mtm1Unc/B2mtm1Unc
Il2rgtm1.1Asin/Il2rgtm1Wjl
Tg(Cd8a*-cre)B8Asin/0
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
B2mtm1Unc mutation (38 available); any B2m mutation (122 available)
Il2rgtm1.1Asin mutation (1 available); any Il2rg mutation (179 available)
Il2rgtm1Wjl mutation (83 available); any Il2rg mutation (179 available)
Tg(Cd8a*-cre)B8Asin mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system

hematopoietic system




Genotype
MGI:5469012
cn2
Allelic
Composition		 Il2rgtm1.1Asin/Il2rgtm1Wjl
Tg(Cd8a*-cre)B8Asin/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il2rgtm1.1Asin mutation (1 available); any Il2rg mutation (179 available)
Il2rgtm1Wjl mutation (83 available); any Il2rg mutation (179 available)
Tg(Cd8a*-cre)B8Asin mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased CD8-positive, alpha-beta T cell number ( J:190889 )
• in the thymus but not the periphery due to lymphopenia-induced homeostatic expansion
decreased NK T cell number ( J:190889 )
• of invariant NK T cells in the thymus, spleen and liver
decreased regulatory T cell number ( J:190889 )
• of CD4 single-positive thymocytes expressing Foxp3
• however, these cells are restored by a cross with Tg(LCKprBCL2)36Sjk mice

hematopoietic system
decreased CD8-positive, alpha-beta T cell number ( J:190889 )
• in the thymus but not the periphery due to lymphopenia-induced homeostatic expansion
decreased NK T cell number ( J:190889 )
• of invariant NK T cells in the thymus, spleen and liver
decreased regulatory T cell number ( J:190889 )
• of CD4 single-positive thymocytes expressing Foxp3
• however, these cells are restored by a cross with Tg(LCKprBCL2)36Sjk mice




Genotype
MGI:5469013
cn3
Allelic
Composition		 Il2rgtm1.1Asin/Il2rgtm1Wjl
Tg(Cd8a*-cre)B8Asin/0
Tg(LCKprBCL2)36Sjk/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il2rgtm1.1Asin mutation (1 available); any Il2rg mutation (179 available)
Il2rgtm1Wjl mutation (83 available); any Il2rg mutation (179 available)
Tg(Cd8a*-cre)B8Asin mutation (1 available)
Tg(LCKprBCL2)36Sjk mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased NK T cell number ( J:190889 )
• of invariant NK T cells as in Il2rgtm1.1Asin/Il2rgtm1Wjl Tg(Cd8a*-cre)#Asin mice

hematopoietic system
decreased NK T cell number ( J:190889 )
• of invariant NK T cells as in Il2rgtm1.1Asin/Il2rgtm1Wjl Tg(Cd8a*-cre)#Asin mice




Genotype
MGI:5469011
cn4
Allelic
Composition		 Il2rgtm1.1Asin/Il2rgtm1Wjl
Tg(Cd4-cre)1Cwi/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il2rgtm1.1Asin mutation (1 available); any Il2rg mutation (179 available)
Il2rgtm1Wjl mutation (83 available); any Il2rg mutation (179 available)
Tg(Cd4-cre)1Cwi mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system

hematopoietic system




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory