Phenotypes associated with this allele

• Allele Symbol: Tlr4^tm1Djh
• Allele Name: targeted mutation 1, David J Hackam
• Allele ID: MGI:5469002
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Tlr4^tm1Djh/Tlr4^tm1Djh Tg(Vil1-cre)997Gum/0	involves: C57BL/6 * C57BL/6J * FVB/N * SJL	MGI:5520917

Genotype
MGI:5520917

cn1

• Allelic Composition: Tlr4^tm1Djh/Tlr4^tm1Djh; Tg(Vil1-cre)997Gum/0
• Genetic Background: involves: C57BL/6 * C57BL/6J * FVB/N * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal bile salt level ( J:193668 )

• reduced in the ileal lumen and stool

decreased susceptibility to injury ( J:193668 )

• following induction of necrotizing enterocolitis, mice exhibit preservation of the small intestinal mucosa and minimal cytokine elevation compared with wild-type mice

digestive/alimentary system

abnormal intestinal goblet cell morphology ( J:193668 )

• increased goblet-like cells, more apparent along the duodenum-jejunum-ileum axis

cellular

abnormal intestinal goblet cell morphology ( J:193668 )

• increased goblet-like cells, more apparent along the duodenum-jejunum-ileum axis