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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Map3k2tm1Rdbr
targeted mutation 1, R Dale Brown
MGI:5469064
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Map3k2tm1Rdbr/Map3k2tm1Rdbr involves: 129S1/Sv * 129S1/SvImj * 129X1/SvJ MGI:5469079


Genotype
MGI:5469079
hm1
Allelic
Composition		 Map3k2tm1Rdbr/Map3k2tm1Rdbr
Genetic
Background		 involves: 129S1/Sv * 129S1/SvImj * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map3k2tm1Rdbr mutation (0 available); any Map3k2 mutation (42 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system

cardiovascular system
decreased response of heart to induced stress ( J:192835 )
• mice subjected to chronic hypoxia to induce pulmonary hypertension exhibit attenuated right ventricle hypertrophy and cardiac myocyte hypertrophy compared with wild-type mice
• however, mice exhibit pulmonary hypertension when exposed to chronic

homeostasis/metabolism
decreased response of heart to induced stress ( J:192835 )
• mice subjected to chronic hypoxia to induce pulmonary hypertension exhibit attenuated right ventricle hypertrophy and cardiac myocyte hypertrophy compared with wild-type mice
• however, mice exhibit pulmonary hypertension when exposed to chronic




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory