About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tc(HSA7;HSA14)#Mtos
transchromosomal, human 7 and human 14, Mitsuo Oshimura
MGI:5469115
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Cyp3a13tm1Mtos/Cyp3a13tm1Mtos
Del(5Cyp3a57-Cyp3a59)1Mtos/+
Tc(HSA7;HSA14)#Mtos/0 		involves: C57BL/6NCrlj * CBA/JNCrlj MGI:5469273


Genotype
MGI:5469273
cx1
Allelic
Composition		 Cyp3a13tm1Mtos/Cyp3a13tm1Mtos
Del(5Cyp3a57-Cyp3a59)1Mtos/+
Tc(HSA7;HSA14)#Mtos/0
Genetic
Background		 involves: C57BL/6NCrlj * CBA/JNCrlj
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cyp3a13tm1Mtos mutation (1 available); any Cyp3a13 mutation (39 available)
Del(5Cyp3a57-Cyp3a59)1Mtos mutation (1 available); any Del(5Cyp3a57-Cyp3a59)1Mtos mutation (1 available)
Tc(HSA7;HSA14)#Mtos mutation (0 available); any Tc(HSA7;HSA14)#Mtos mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
abnormal enzyme/coenzyme activity ( J:191214 )
• the kinetics of alpha-OH triazolam (TRZ) in the liver are similar to those of humans but not mice
• the CYP3A-mediated mechanism-based inactivation effects and formation of fetal-specific metabolites of dehydroepiandrosterone observed in humans is well reproduced




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory