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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Del(5Cyp3a57-Cyp3a59)1Mtos
deletion, Chr 5, Mitsuo Oshimura 1
MGI:5469199
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Cyp3a13tm1Mtos/Cyp3a13tm1Mtos
Del(5Cyp3a57-Cyp3a59)1Mtos/+
Tc(HSA7;HSA14)#Mtos/0 		involves: C57BL/6NCrlj * CBA/JNCrlj MGI:5469273


Genotype
MGI:5469273
cx1
Allelic
Composition		 Cyp3a13tm1Mtos/Cyp3a13tm1Mtos
Del(5Cyp3a57-Cyp3a59)1Mtos/+
Tc(HSA7;HSA14)#Mtos/0
Genetic
Background		 involves: C57BL/6NCrlj * CBA/JNCrlj
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cyp3a13tm1Mtos mutation (1 available); any Cyp3a13 mutation (39 available)
Del(5Cyp3a57-Cyp3a59)1Mtos mutation (1 available); any Del(5Cyp3a57-Cyp3a59)1Mtos mutation (1 available)
Tc(HSA7;HSA14)#Mtos mutation (0 available); any Tc(HSA7;HSA14)#Mtos mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
abnormal enzyme/coenzyme activity ( J:191214 )
• the kinetics of alpha-OH triazolam (TRZ) in the liver are similar to those of humans but not mice
• the CYP3A-mediated mechanism-based inactivation effects and formation of fetal-specific metabolites of dehydroepiandrosterone observed in humans is well reproduced




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory