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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Igs4tm1Hsas
targeted mutation 1, Hiroyuki Sasaki
MGI:5469286
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Igs4tm1Hsas/Igs4tm1Hsas involves: 129S4/SvJae MGI:5469307
cn2
Gt(ROSA)26Sor/Gt(ROSA)26Sor
Igs4tm1Hsas/Igs4tm1Hsas
Tg(CAG-cre)13Miya/0
involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6 MGI:5469309
cx3
Gt(ROSA)26Sor/Gt(ROSA)26Sor
Igs4tm1Hsas/Igs4tm1Hsas
involves: 129S4/SvJae * 129S7/SvEvBrd MGI:5469308


Genotype
MGI:5469307
hm1
Allelic
Composition
Igs4tm1Hsas/Igs4tm1Hsas
Genetic
Background
involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• although no homozygous mice are identified this may indicate a problem with genotyping since the J1 ES cells used to generate mice contains a duplication in this area and the ratio of heterozygotes to wild-type mice is twice as much as expected from crosses involving heterozygous parents




Genotype
MGI:5469309
cn2
Allelic
Composition
Gt(ROSA)26Sor/Gt(ROSA)26Sor
Igs4tm1Hsas/Igs4tm1Hsas
Tg(CAG-cre)13Miya/0
Genetic
Background
involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor mutation (17 available); any Gt(ROSA)26Sor mutation (993 available)
Igs4tm1Hsas mutation (0 available); any Igs4 mutation (0 available)
Tg(CAG-cre)13Miya mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
N
• reporter expression is recovered following cre-mediated removal of the neo sequence from the Watson piwiRNA generating locus on chromosome 17




Genotype
MGI:5469308
cx3
Allelic
Composition
Gt(ROSA)26Sor/Gt(ROSA)26Sor
Igs4tm1Hsas/Igs4tm1Hsas
Genetic
Background
involves: 129S4/SvJae * 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor mutation (17 available); any Gt(ROSA)26Sor mutation (993 available)
Igs4tm1Hsas mutation (0 available); any Igs4 mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• the reporter is post-transcriptionally repressed after the time of pachytene piRNA generation
• however, no change in reporter locus methylation is detected





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/19/2024
MGI 6.24
The Jackson Laboratory