All Phenotypes Vps52<t-w5> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Vps52^t-w5
t, wild 5
MGI:5469352

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	t^w5/t^w5 Vps52^t-w5/Vps52^t-w5	B6.Cg-t^w5	MGI:5464109
cx2	Vps52^tm1.2Kab/t^w5 Vps52^t-w5	involves: C57BL * C57BL/6 * CBA/JNCrlj * DBA	MGI:5464110

Allelic Composition	t^w5/t^w5 Vps52^t-w5/Vps52^t-w5
Genetic Background	B6.Cg-t^w5

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
t^w5 mutation (3 available); any t mutation (19 available)
Vps52^t-w5 mutation (0 available); any Vps52 mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

abnormal ectoderm development ( J:190873 )

• the epithelial layer of the embryonic ectoderm fails to form by E6.5

• cell proliferation is very low in the embryonic ectoderm

• however, formation of extraembryonic tissues is similar to controls

decreased embryo size ( J:190873 )

• at E6.5

abnormal blastocyst morphology ( J:190873 )

• absence of cavitation in embryonic tissues; however, cavitation is seen in extraembryonic tissues

growth/size/body

decreased embryo size ( J:190873 )

• at E6.5

Allelic Composition	Vps52^tm1.2Kab/t^w5 Vps52^t-w5
Genetic Background	involves: C57BL * C57BL/6 * CBA/JNCrlj * DBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
t^w5 mutation (3 available); any t mutation (19 available)
Vps52^tm1.2Kab mutation (1 available); any Vps52 mutation (42 available)
Vps52^t-w5 mutation (0 available); any Vps52 mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

abnormal ectoderm development ( J:190873 )

• at E6.5 all embryos show embryonic ectoderm defects typical of mice homozygous for t^w5

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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