Phenotypes associated with this allele

• Allele Symbol: Otoa^tm1Gpr
• Allele Name: targeted mutation 1, Guy P Richardson
• Allele ID: MGI:5469411
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Otoa^tm1Gpr/Otoa^tm1Gpr	involves: 129S/SvEv	MGI:5469422

Genotype
MGI:5469422

hm1

• Allelic Composition: Otoa^tm1Gpr/Otoa^tm1Gpr
• Genetic Background: involves: 129S/SvEv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

The tectorial membrane of Otoa^tm1Gpr/Otoa^tm1Gpr mice is detached from spiral limbus

hearing/vestibular/ear

hearing/vestibular/ear phenotype ( J:192263 )

N • mice exhibit normal cochlear microphonic potentials and cochlear amplification

absent Hensen stripe ( J:192263 )

• absent Hensen's stripe

abnormal tectorial membrane morphology ( J:192263 )

• thin lateral-most region, frequently fenestrated

• slightly tilted with the lateral region displaced medially

• however, the orientation and organization of hair cells is normal

detached tectorial membrane ( J:192263 )

• from the spiral limbus

abnormal cochlear nerve compound action potential ( J:192263 )

• elevated cochlear nerve compound action potential threshold

impaired hearing ( J:192263 )

• elevated cochlear nerve compound action potential threshold

nervous system

abnormal cochlear nerve compound action potential ( J:192263 )

• elevated cochlear nerve compound action potential threshold

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
autosomal recessive nonsyndromic deafness 22		DOID:0110480	OMIM:607039	J:192263