Analysis Tools|
Allele Symbol Allele Name Allele ID |
Pik3catm1Gne targeted mutation 1, Genentech MGI:5469577 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• thoracic and inguino-abdominal mammary gland tumors with latency dependent on nulliparous or multiparous condition
• however, treatment with PI3K inhibitor inhibits tumor growth
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• precocious lobulo-alveolar development and hyper-branched ductal structures (2-fold increase in ductal branch point) at 12 weeks
• feathery, hyper-branched ductal tree by 50 weeks
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• thoracic and inguino-abdominal mammary gland tumors with latency dependent on nulliparous or multiparous condition
• however, treatment with PI3K inhibitor inhibits tumor growth
|
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• precocious lobulo-alveolar development and hyper-branched ductal structures (2-fold increase in ductal branch point) at 12 weeks
• feathery, hyper-branched ductal tree by 50 weeks
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• thoracic and inguino-abdominal mammary gland tumors with latency dependent on nulliparous or multiparous condition
• however, treatment with PI3K inhibitor inhibits tumor growth
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| breast cancer | DOID:1612 |
OMIM:114480 |
J:193377 | |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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N