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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Syngap1tm2Geno
targeted mutation 2, Genoway
MGI:5469866
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Syngap1tm2Geno/Syngap1+
Tg(CAG-cre/Esr1*)5Amc/0
involves: 129S2/SvPas * C57BL/6 * CBA MGI:5469879
cx2
Syngap1tm2Geno/Syngap1+
Tg(CAG-cre/Esr1*)5Amc/0
involves: 129S2/SvPas * C57BL/6 * CBA MGI:5469878


Genotype
MGI:5469879
cn1
Allelic
Composition
Syngap1tm2Geno/Syngap1+
Tg(CAG-cre/Esr1*)5Amc/0
Genetic
Background
involves: 129S2/SvPas * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Syngap1tm2Geno mutation (1 available); any Syngap1 mutation (49 available)
Tg(CAG-cre/Esr1*)5Amc mutation (10 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• mice exhibit behavioral abnormalities as in Syngap1tm1Rlh heterozygotes
• untreated mice and mice treated with tamoxifen in adulthood exhibit absence of spontaneous alteration in a T-maze compared with control mice
• untreated mice and mice treated with tamoxifen in adulthood spend increased time in open arms of an elevated plus maze compared with control mice
• untreated mice and mice treated with tamoxifen in adulthood exhibit increased activity in an open field compared with control mice




Genotype
MGI:5469878
cx2
Allelic
Composition
Syngap1tm2Geno/Syngap1+
Tg(CAG-cre/Esr1*)5Amc/0
Genetic
Background
involves: 129S2/SvPas * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Syngap1tm2Geno mutation (1 available); any Syngap1 mutation (49 available)
Tg(CAG-cre/Esr1*)5Amc mutation (10 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• mice exhibit behavioral abnormalities as in Syngap1tm1Rlh heterozygotes
• untreated mice and mice treated with tamoxifen in adulthood exhibit absence of spontaneous alteration in a T-maze compared with control mice
• untreated mice and mice treated with tamoxifen in adulthood spend increased time in open arms of an elevated plus maze compared with control mice
• untreated mice and mice treated with tamoxifen in adulthood exhibit increased activity in an open field compared with control mice





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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory