Phenotypes associated with this allele

• Allele Symbol: Pilra^tm1Osb
• Allele Name: targeted mutation 1, Research Institute for Microbial Diseases, Osaka University
• Allele ID: MGI:5469884
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pilra^tm1Osb/Pilra^tm1Osb	B6.129-Pilra^tm1Osb	MGI:5469889

Genotype
MGI:5469889

hm1

• Allelic Composition: Pilra^tm1Osb/Pilra^tm1Osb
• Genetic Background: B6.129-Pilra^tm1Osb

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to bacterial infection induced morbidity/mortality ( J:191085 )

• following intraperitoneal LPS injection

immune system

abnormal leukocyte adhesion ( J:191085 )

• neutrophils exhibit increased static adhesion to immobilized ICAM1 after fMLF stimulation compared with wild-type cells

increased neutrophil cell number ( J:191085 )

• following intraperitoneal LPS injection

abnormal neutrophil physiology ( J:191085 )

• neutrophils exhibit increased neutrophil recruitment in vivo in a thioglycollate-induced sterile peritonitis model, chemotaxis toward the chemoattractant fMLF and CXCL1, static adhesion to immobilized ICAM1 after fMLF stimulation, and calcium responses after fMLF treatment compared with wild-type cells

increased susceptibility to endotoxin shock ( J:191085 )

• following intraperitoneal LPS injection, mice exhibit increased alanine transferase, blood urea nitrogen, lactate dehydrogenase, neutrophils and mortality and altered liver morphology (massive hemorrhage, disorganized hepatic cords and karyolysis of hepatocytes) compared with wild-type mice

• however, cytokine production is normal

increased susceptibility to bacterial infection induced morbidity/mortality ( J:191085 )

• following intraperitoneal LPS injection

liver/biliary system

liver hemorrhage ( J:191085 )

• massive following intraperitoneal LPS injection

abnormal hepatic cord morphology ( J:191085 )

• disorganized hepatic cords following intraperitoneal LPS injection

abnormal hepatocyte physiology ( J:191085 )

• karyolysis of hepatocytes following intraperitoneal LPS injection

cardiovascular system

liver hemorrhage ( J:191085 )

• massive following intraperitoneal LPS injection

cellular

abnormal leukocyte adhesion ( J:191085 )

• neutrophils exhibit increased static adhesion to immobilized ICAM1 after fMLF stimulation compared with wild-type cells

hematopoietic system

abnormal leukocyte adhesion ( J:191085 )

• neutrophils exhibit increased static adhesion to immobilized ICAM1 after fMLF stimulation compared with wild-type cells

increased neutrophil cell number ( J:191085 )

• following intraperitoneal LPS injection

abnormal neutrophil physiology ( J:191085 )

• neutrophils exhibit increased neutrophil recruitment in vivo in a thioglycollate-induced sterile peritonitis model, chemotaxis toward the chemoattractant fMLF and CXCL1, static adhesion to immobilized ICAM1 after fMLF stimulation, and calcium responses after fMLF treatment compared with wild-type cells

homeostasis/metabolism

increased blood urea nitrogen level ( J:191085 )

• following intraperitoneal LPS injection

increased circulating alanine transaminase level ( J:191085 )

• following intraperitoneal LPS injection

increased circulating lactate dehydrogenase level ( J:191085 )

• increased in the serum following intraperitoneal LPS injection