mortality/aging
• no mice are observed after E13.5
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hematopoietic system
• one line exhibited increased immature hematopoietic progenitors and decreased mature hematopoietic progenitors compared with wild-type mice
• at E12.5, mice exhibit a block in definite hematopoiesis
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cardiovascular system
• in the central nervous system
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nervous system
• in the central nervous system
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