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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Cbfbtm5Ppl
targeted mutation 5, Pu P Liu
MGI:5469976
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Cbfbtm5Ppl/Cbfbtm5Ppl Not Specified MGI:5470055
ht2
Cbfbtm5Ppl/Cbfb+ Not Specified MGI:5470056


Genotype
MGI:5470055
hm1
Allelic
Composition
Cbfbtm5Ppl/Cbfbtm5Ppl
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cbfbtm5Ppl mutation (0 available); any Cbfb mutation (36 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

hematopoietic system
• one line exhibited increased immature hematopoietic progenitors and decreased mature hematopoietic progenitors compared with wild-type mice
• at E12.5, mice exhibit a block in definite hematopoiesis

cardiovascular system
• in the central nervous system

nervous system
• in the central nervous system




Genotype
MGI:5470056
ht2
Allelic
Composition
Cbfbtm5Ppl/Cbfb+
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cbfbtm5Ppl mutation (0 available); any Cbfb mutation (36 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• bone marrow cells from mice treated with ENU produce more granulocyte and macrophage (CFU-GM) colonies compared with wild-type mice
• some aged mice treated with ENU develop myeloproliferative disease with increased Mac1/Gr1+ cells in the peripheral blood
• increased myelopoiesis in the bone marrow and spleen of some aged mice treated with ENU
• however, cells do not exhibit a blast-like appearance and transplanted cells do not result in abnormal myelopoiesis in recipient mice

neoplasm
N
• ENU-treated mice do not develop leukemia

cellular
• bone marrow cells from mice treated with ENU produce more granulocyte and macrophage (CFU-GM) colonies compared with wild-type mice

immune system
• bone marrow cells from mice treated with ENU produce more granulocyte and macrophage (CFU-GM) colonies compared with wild-type mice
• some aged mice treated with ENU develop myeloproliferative disease with increased Mac1/Gr1+ cells in the peripheral blood
• increased myelopoiesis in the bone marrow and spleen of some aged mice treated with ENU
• however, cells do not exhibit a blast-like appearance and transplanted cells do not result in abnormal myelopoiesis in recipient mice





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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory