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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Pfn1tm1Foxp
targeted mutation 1, Paul L Fox
MGI:5470084
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Pfn1tm1Foxp/Pfn1tm1Foxp involves: C57BL/6NTac MGI:5470090
cn2
 		Pfn1tm1Foxp/Pfn1tm1Foxp
Tg(Tek-cre)1Ywa/0 		involves: C57BL/6 * C57BL/6NTac * SJL MGI:5470091
cn3
 		Pfn1tm1Foxp/Pfn1tm1Foxp
Tg(Cdh5-cre/ERT2)1Rha/0 		involves: C57BL/6NTac MGI:5470092


Genotype
MGI:5470090
hm1
Allelic
Composition		 Pfn1tm1Foxp/Pfn1tm1Foxp
Genetic
Background		 involves: C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pfn1tm1Foxp mutation (0 available); any Pfn1 mutation (12 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:193938 )
• mice are viable and fertile




Genotype
MGI:5470091
cn2
Allelic
Composition		 Pfn1tm1Foxp/Pfn1tm1Foxp
Tg(Tek-cre)1Ywa/0
Genetic
Background		 involves: C57BL/6 * C57BL/6NTac * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pfn1tm1Foxp mutation (0 available); any Pfn1 mutation (12 available)
Tg(Tek-cre)1Ywa mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal vascular endothelial cell migration ( J:193938 )
• endothelial cell planar migration stimulated by VEGF-A is inhibited compared with control cells

cardiovascular system
decreased angiogenesis ( J:193938 )
• angiogenesis after ischemia or skin punch is impaired
• however, mice exhibit normal developmental angiogenesis
abnormal vascular endothelial cell migration ( J:193938 )
• endothelial cell planar migration stimulated by VEGF-A is inhibited compared with control cells
abnormal vascular wound healing ( J:193938 )
• after skin punch, mice exhibit fewer microvessels within the healing wound and larger blood vessels in the region surrounding the injury compared with control mice

homeostasis/metabolism
abnormal vascular wound healing ( J:193938 )
• after skin punch, mice exhibit fewer microvessels within the healing wound and larger blood vessels in the region surrounding the injury compared with control mice
delayed wound healing ( J:193938 )
• after skin punch




Genotype
MGI:5470092
cn3
Allelic
Composition		 Pfn1tm1Foxp/Pfn1tm1Foxp
Tg(Cdh5-cre/ERT2)1Rha/0
Genetic
Background		 involves: C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pfn1tm1Foxp mutation (0 available); any Pfn1 mutation (12 available)
Tg(Cdh5-cre/ERT2)1Rha mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
decreased angiogenesis ( J:193938 )
• after ischemia, tamoxifen-treated mice exhibit impaired angiogenesis and reduced perfusion compared with control mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory