Phenotypes associated with this allele

• Allele Symbol: Nol3^tm1.1Rnkt
• Allele Name: targeted mutation 1.1, Richard N Kitsis
• Allele ID: MGI:5470099
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nol3^tm1.1Rnkt/Nol3^tm1.1Rnkt	B6.129-Nol3^tm1.1Rnkt	MGI:5470100

Genotype
MGI:5470100

hm1

• Allelic Composition: Nol3^tm1.1Rnkt/Nol3^tm1.1Rnkt
• Genetic Background: B6.129-Nol3^tm1.1Rnkt

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal lung vasculature morphology ( J:193803 )

• pulmonary vasculature remodeling induced by chronic hypoxia is attenuated compared with wild-type mice

abnormal pulmonary pressure ( J:193803 )

• pulmonary hypertension induced by chronic hypoxia is attenuated compared with wild-type mice

homeostasis/metabolism

decreased susceptibility to injury ( J:193803 )

• exposure to chronic hypoxia induces only modest increases in mean pulmonary arterial and right ventricular systolic pressure, less prominent right ventricle hypertrophy without a change in cardiac output and attenuated pulmonary vasculature remodeling compared with wild-type mice

cellular

increased apoptosis ( J:193803 )

• in pulmonary vasculature under chronic hypoxia

decreased cell proliferation ( J:193803 )

• in pulmonary vasculature under chronic hypoxia

respiratory system

abnormal lung vasculature morphology ( J:193803 )

• pulmonary vasculature remodeling induced by chronic hypoxia is attenuated compared with wild-type mice