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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Zic3tm2.1Jwb
targeted mutation 2.1, John W Belmont
MGI:5470150
Summary 7 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Zic3tm2.1Jwb/Zic3tm2.1Jwb involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6J MGI:5470167
cn2
 		Zic3tm2.1Jwb/Y
Tg(T-cre)1Lwd/0 		involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C3H * C57BL/6 MGI:5470172
cn3
 		Zic3tm2.1Jwb/Y
Edil3Tg(Sox2-cre)1Amc/Edil3+ 		involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6 * CBA MGI:5470168
cn4
 		Mesp1tm2(cre)Ysa/Mesp1+
Zic3tm2.1Jwb/Y 		involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6 * CBA/JNCrlj MGI:5470171
cn5
 		Nkx2-5tm1(cre)Rjs/Nkx2-5+
Zic3tm2.1Jwb/Y 		involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6J MGI:5470169
cn6
 		Zic3tm2.1Jwb/Y
H2az2Tg(Wnt1-cre)11Rth/H2az2+ 		involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6J * CBA/J MGI:5470170
ot7
 		Zic3tm2.1Jwb/Y involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6J MGI:5470166


Genotype
MGI:5470167
hm1
Allelic
Composition		 Zic3tm2.1Jwb/Zic3tm2.1Jwb
Genetic
Background		 involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zic3tm2.1Jwb mutation (1 available); any Zic3 mutation (38 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:192577 )
• mice are viable and fertile and phenotypically indistinguishable from the wild-type mice




Genotype
MGI:5470172
cn2
Allelic
Composition		 Zic3tm2.1Jwb/Y
Tg(T-cre)1Lwd/0
Genetic
Background		 involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C3H * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(T-cre)1Lwd mutation (1 available)
Zic3tm2.1Jwb mutation (1 available); any Zic3 mutation (38 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
preweaning lethality, incomplete penetrance ( J:192577 )
• despite normal numbers at E9.5, fewer than expected mice at E15.5 and weaning

cardiovascular system
abnormal heart looping ( J:192577 )
• in 4 of 22 mice

limbs/digits/tail

growth/size/body
heterotaxia ( J:192577 )
• laterality defects in 4 of 18 mice




Genotype
MGI:5470168
cn3
Allelic
Composition		 Zic3tm2.1Jwb/Y
Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic
Background		 involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edil3Tg(Sox2-cre)1Amc mutation (5 available); any Edil3 mutation (43 available)
Zic3tm2.1Jwb mutation (1 available); any Zic3 mutation (38 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
lethality throughout fetal growth and development, incomplete penetrance ( J:192577 )
• despite normal numbers at E15.5, fewer than expected mice at weaning

cardiovascular system
abnormal inferior vena cava morphology ( J:192577 )
• separate entrance of hepatic veins in some mice
abnormal heart looping ( J:192577 )
• in 5 of 32 mice at E9.5
atrial septal defect ( J:192577 )
• in some mice
abnormal heart position or orientation ( J:192577 )
• atrium isomerism in some mice
dextrocardia ( J:192577 )
• in some mice
ventricular septal defect ( J:192577 )
• in some mice

digestive/alimentary system
cleft palate ( J:192577 )
• in 4 of 38 mice at E15.5
abnormal anus morphology ( J:192577 )
• in some mice
abnormal stomach position or orientation ( J:192577 )
• midline and right-sided stomach in some mice
right-sided stomach ( J:192577 )
• in some mice

embryo
abnormal embryo development ( J:192577 )
• in some mice at E9.5
embryonic growth retardation ( J:192577 )
• in 14 of 32 mice
abnormal neural tube morphology ( J:192577 )
• in 4 of 38 mice at E15.5

growth/size/body
cleft palate ( J:192577 )
• in 4 of 38 mice at E15.5
embryonic growth retardation ( J:192577 )
• in 14 of 32 mice
heterotaxia ( J:192577 )
• laterality defects in 2 of 8 mice
right-sided stomach ( J:192577 )
• in some mice

nervous system
abnormal neural tube morphology ( J:192577 )
• in 4 of 38 mice at E15.5
exencephaly ( J:192577 )
• in 4 of 38 mice at E15.5

behavior/neurological
hindlimb paralysis ( J:192577 )
• in some mice

vision/eye
abnormal eye morphology ( J:192577 )
• in some mice

skeleton

respiratory system
abnormal lung position or orientation ( J:192577 )
• pulmonary isomerism in some mice

limbs/digits/tail

craniofacial
cleft palate ( J:192577 )
• in 4 of 38 mice at E15.5




Genotype
MGI:5470171
cn4
Allelic
Composition		 Mesp1tm2(cre)Ysa/Mesp1+
Zic3tm2.1Jwb/Y
Genetic
Background		 involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6 * CBA/JNCrlj
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mesp1tm2(cre)Ysa mutation (3 available); any Mesp1 mutation (18 available)
Zic3tm2.1Jwb mutation (1 available); any Zic3 mutation (38 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:192577 )
• mice are indistinguishable from control mice with normal survival and heart development




Genotype
MGI:5470169
cn5
Allelic
Composition		 Nkx2-5tm1(cre)Rjs/Nkx2-5+
Zic3tm2.1Jwb/Y
Genetic
Background		 involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nkx2-5tm1(cre)Rjs mutation (1 available); any Nkx2-5 mutation (21 available)
Zic3tm2.1Jwb mutation (1 available); any Zic3 mutation (38 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:192577 )
• mice are indistinguishable from control mice with normal survival and heart development




Genotype
MGI:5470170
cn6
Allelic
Composition		 Zic3tm2.1Jwb/Y
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Genetic
Background		 involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6J * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (26 available)
Zic3tm2.1Jwb mutation (1 available); any Zic3 mutation (38 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:192577 )
• mice are indistinguishable from control mice with normal survival and heart development




Genotype
MGI:5470166
ot7
Allelic
Composition		 Zic3tm2.1Jwb/Y
Genetic
Background		 involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zic3tm2.1Jwb mutation (1 available); any Zic3 mutation (38 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:192577 )
• mice are viable and fertile and phenotypically indistinguishable from the wild-type mice




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory