Phenotypes associated with this allele

• Allele Symbol: Del(Y)4H
• Allele Name: deletion, Chr Y, 4 Harwell
• Allele ID: MGI:5470161
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ot1	X/Del(Y)4H	mixed	MGI:5470162

Genotype
MGI:5470162

ot1

• Allelic Composition: X/Del(Y)4H
• Genetic Background: mixed

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

sex reversal ( J:194031 )

• Background Sensitivity: crosses of X/Y^Del(Y)4H male mice to females of C57BL/6 or closely related strains yielded 573 female-appearing and 170 male-appearing (and 4 sexually indeterminate) progeny, the likelihood of which (P-value; by X² analysis) is <0.001; of 55 apparent females analyzed cytologically, 40 were XX, 1 XO and 14 XY, suggesting that on a predominantly C57BL/6 background, approximately 50% of X/Y^Del(Y)4H mice develop outwardly as females.

• the relative proportions of apparently female to outwardly male progeny from crosses of X/Y^Del(Y)4H male mice to C3H/HeH and (C3H/HeH x 101/H)F1 females (4 and 117 female, respectively, and 95 and 11 male, respectively) are not significantly skewed (C3H/HeH: X²=3.27, P=0.07056; C3H101H: X²=2.283, P=0.13) toward phenotypic females, and the apparent preponderance of females becomes less so with increasing contribution of C3H/HeH and 101/H to the genetic background, suggesting that sex reversal to female of X/Y^Del(Y)4H animals rarely or never occurs on this background.