Phenotypes associated with this allele

• Allele Symbol: Polg2^tm1.1Wcc
• Allele Name: targeted mutation 1.1, William C Copeland
• Allele ID: MGI:5470227
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Polg2^tm1.1Wcc/Polg2^tm1.1Wcc	involves: C57BL/6 * CBA	MGI:5470233

Genotype
MGI:5470233

hm1

• Allelic Composition: Polg2^tm1.1Wcc/Polg2^tm1.1Wcc
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality between somite formation and embryo turning, complete penetrance ( J:192568 )

• mice die between E8.0 and E8.5

cellular

abnormal mitochondrial morphology ( J:192568 )

• increase in fatty droplet with swollen and disorganized cristae

decreased mitochondrial DNA content ( J:192568 )

disorganized mitochondrial cristae ( J:192568 )

• swollen and disorganized cristae

abnormal respiratory electron transport chain ( J:192568 )

• complete lack of COX1(mt-Co1) activity

embryo

failure of initiation of embryo turning ( J:192568 )