Analysis Tools
mortality/aging
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• mice die between 2 and 6 weeks after birth, with about 50% dead by the third week of age
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• mice die between 2 and 6 weeks after birth, with about 50% dead by the third week of age
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growth/size/body
weight loss
(
J:127628
)
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• mice become slightly smaller beginning at P9 and display markedly smaller body statures by P16 and weigh less than half the wild-type littermates after 3 weeks of age
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• at P0, kidneys contain a few microcysts in the subcortical region, from P1-P5, the number and size of cysts increases, initially in the cortex and then extending into the medulla, and by P14, cysts replace most of the normal renal parenchyma except for the papillae tip, and massive cystic kidneys by P22-P28
• most cysts are of collecting duct origin, indicating that renal tubular cystic dilation involves primarily distal nephron segments
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• mice exhibit distended abdomens at P16
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• mice at P9 and P16 have pale, grossly enlarged cystic kidneys
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homeostasis/metabolism
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• mice have elevated blood urea nitrogen levels at P14 and P23
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liver/biliary system
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• mice at P9 and P16 exhibit dilated common bile ducts
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endocrine/exocrine glands
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• mice at P9 and P16 exhibit dilated common bile ducts
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renal/urinary system
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• at P0, kidneys contain a few microcysts in the subcortical region, from P1-P5, the number and size of cysts increases, initially in the cortex and then extending into the medulla, and by P14, cysts replace most of the normal renal parenchyma except for the papillae tip, and massive cystic kidneys by P22-P28
• most cysts are of collecting duct origin, indicating that renal tubular cystic dilation involves primarily distal nephron segments
|
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• mice at P9 and P16 have pale, grossly enlarged cystic kidneys
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• mice show rapid and progressive tubular dilation of the kidneys during the postnatal maturation stage
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