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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Hoxb2tm2.2Fmr
targeted mutation 2.2, Filippo M Rijli
MGI:5470287
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Hoxb2tm2.2Fmr/Hoxb2tm2.2Fmr involves: C57BL/6 * SJL MGI:5470405
cx2
 		Hoxa2tm2.1Fmr/Hoxa2tm2.1Fmr
Hoxb2tm2.2Fmr/Hoxb2tm2.2Fmr 		involves: 129S2/SvPas * C57BL/6 * SJL MGI:5470407


Genotype
MGI:5470405
hm1
Allelic
Composition		 Hoxb2tm2.2Fmr/Hoxb2tm2.2Fmr
Genetic
Background		 involves: C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxb2tm2.2Fmr mutation (0 available); any Hoxb2 mutation (12 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal brain development ( J:193058 )
• decreased oligodendrogenesis in the pontine territory (rhombomere 4-derived)
decreased oligodendrocyte progenitor number ( J:193058 )
• in the pontine territory (rhombomere 4-derived) due to reduced proliferation
• however, oligodendrocyte progenitor cell and mature oligodendrocyte numbers are normal at E18.5

cellular
decreased oligodendrocyte progenitor number ( J:193058 )
• in the pontine territory (rhombomere 4-derived) due to reduced proliferation
• however, oligodendrocyte progenitor cell and mature oligodendrocyte numbers are normal at E18.5




Genotype
MGI:5470407
cx2
Allelic
Composition		 Hoxa2tm2.1Fmr/Hoxa2tm2.1Fmr
Hoxb2tm2.2Fmr/Hoxb2tm2.2Fmr
Genetic
Background		 involves: 129S2/SvPas * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxa2tm2.1Fmr mutation (0 available); any Hoxa2 mutation (21 available)
Hoxb2tm2.2Fmr mutation (0 available); any Hoxb2 mutation (12 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal brain development ( J:193058 )
• increased oligodendrogenesis in the rhombomere 2-derived, but not rhombomere 3-derived, territory at E13.5
• reduced oligodendrogenesis in the pontine territory (rhombomere 4-derived) at E13.5
decreased oligodendrocyte progenitor number ( J:193058 )
• in pontine territory (rhombomere 4-derived) at E13.5 due to reduced proliferation
increased oligodendrocyte progenitor number ( J:193058 )
• in rhombomere 2-derived, but not rhombomere 3-derived, territory at E13.5 due to increased proliferation

cellular
decreased oligodendrocyte progenitor number ( J:193058 )
• in pontine territory (rhombomere 4-derived) at E13.5 due to reduced proliferation
increased oligodendrocyte progenitor number ( J:193058 )
• in rhombomere 2-derived, but not rhombomere 3-derived, territory at E13.5 due to increased proliferation




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory