Phenotypes associated with this allele

• Allele Symbol: Crppa^m1Ddg
• Allele Name: mutation 1, David D Ginty
• Allele ID: MGI:5470460
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Crppa^m1Ddg/Crppa^m1Ddg	involves: C3H/He * C57BL/6	MGI:5470525

Genotype
MGI:5470525

hm1

• Allelic Composition: Crppa^m1Ddg/Crppa^m1Ddg
• Genetic Background: involves: C3H/He * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:194150 )

• mice die at birth due to respiratory failure

nervous system

abnormal axon fasciculation ( J:194150 )

• axons emanating from the midbrain and cranial nerves exhibit descending projections that fail to project through the hindbrain altogether and the central projections of the vagal complex projects aberrantly within the hindbrain compared with wild-type mice

• mice exhibit defects (highly defasciculated, patchy and discontinuous) in the formation of the dorsal funiculus by the central projections of the dorsal root ganglia sensory neurons compared with wild-type mice

abnormal axon guidance ( J:194150 )

• axons emanating from the midbrain and cranial nerves exhibit descending projections that fail to project through the hindbrain altogether and the central projections of the vagal complex projects aberrantly within the hindbrain compared with wild-type mice

radial glial endfoot detachment ( J:194150 )

• endfoot detachment

abnormal nervous system tract morphology ( J:194150 )

• axons emanating from the midbrain and cranial nerves exhibit descending projections that fail to project through the hindbrain altogether and the central projections of the vagal complex projects aberrantly within the hindbrain compared with wild-type mice

abnormal spinal cord ventral commissure morphology ( J:194150 )

• at E11.5, commissural axons exhibit robust postcrossing trajectory defects with failure to project to the lateral portion of the funiculus and altered lateral and ventral funiculi ratio compared with wild-type mice

• at E13, a large number of commissural axons project abnormally within the floor plate unlike in wild-type mice

ectopic neuron ( J:194150 )

• neuronal heterotopias

abnormal spinal cord dorsal column morphology ( J:194150 )

• mice exhibit defects (highly defasciculated, patchy and discontinuous) in the formation of the dorsal funiculus by the central projections of the dorsal root ganglia sensory neurons compared with wild-type mice

respiratory system

respiratory failure ( J:194150 )

• at birth

cellular

abnormal axon fasciculation ( J:194150 )

• axons emanating from the midbrain and cranial nerves exhibit descending projections that fail to project through the hindbrain altogether and the central projections of the vagal complex projects aberrantly within the hindbrain compared with wild-type mice

• mice exhibit defects (highly defasciculated, patchy and discontinuous) in the formation of the dorsal funiculus by the central projections of the dorsal root ganglia sensory neurons compared with wild-type mice

abnormal axon guidance ( J:194150 )

• axons emanating from the midbrain and cranial nerves exhibit descending projections that fail to project through the hindbrain altogether and the central projections of the vagal complex projects aberrantly within the hindbrain compared with wild-type mice

radial glial endfoot detachment ( J:194150 )

• endfoot detachment

abnormal basement membrane morphology ( J:194150 )

• at E11.5, mice exhibit progressive fragmentation of the basement membrane surrounding the spinal cord which is accompanied by detachment of radial neuroepithelial endfeet from the basal surface unlike wild-type mice