All Phenotypes Tg(Prl-cre)1Mrub MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tg(Prl-cre)1Mrub
transgene insertion 1, Marcelo Rubinstein
MGI:5471483

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Drd2^tm1.1Mrub/Drd2^tm1.1Mrub Tg(Prl-cre)1Mrub/?	involves: 129S4/SvJae * C57BL/6 * CBA	MGI:5471747

Allelic Composition	Drd2^tm1.1Mrub/Drd2^tm1.1Mrub Tg(Prl-cre)1Mrub/?
Genetic Background	involves: 129S4/SvJae * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Drd2^tm1.1Mrub mutation (1 available); any Drd2 mutation (70 available)
Tg(Prl-cre)1Mrub mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

growth/size/body region phenotype ( J:194227 )

N	• body weight and body size are normal in males

homeostasis/metabolism

increased circulating prolactin level ( J:194227 )

• hyperprolactinemia in both sexes but particularly in females

decreased physiological sensitivity to xenobiotic ( J:194227 )

• haloperidol fails to increase serum prolactin in either sex as it does in controls

• haloperidol induces catatonia as in controls

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