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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Myh6-Gsk3b*)19Jusa
transgene insertion 19, Junichi Sadoshima
MGI:5471797
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Tg(CAG-EGFP/Map1lc3b)53Nmz/0
Tg(Myh6-Gsk3b*)19Jusa/0 		involves: C57BL/6NCrj * FVB/N MGI:5471802
tg2
 		Tg(Myh6-Gsk3b*)19Jusa/0 involves: FVB MGI:5471803


Genotype
MGI:5471802
cx1
Allelic
Composition		 Tg(CAG-EGFP/Map1lc3b)53Nmz/0
Tg(Myh6-Gsk3b*)19Jusa/0
Genetic
Background		 involves: C57BL/6NCrj * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(CAG-EGFP/Map1lc3b)53Nmz mutation (5 available)
Tg(Myh6-Gsk3b*)19Jusa mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
increased myocardial infarct size ( J:186597 )
• following 2 hours of ischemia without reperfusion
• however, treatment with rapamycin reduces infarct size

cellular
abnormal autophagy ( J:186597 )
• reduced autophagy in the heart following 2 hours of ischemia or ischemia with reperfusion
• however, treatment with rapamycin restores autophagy in both cases

homeostasis/metabolism
increased myocardial infarct size ( J:186597 )
• following 2 hours of ischemia without reperfusion
• however, treatment with rapamycin reduces infarct size
abnormal autophagy ( J:186597 )
• reduced autophagy in the heart following 2 hours of ischemia or ischemia with reperfusion
• however, treatment with rapamycin restores autophagy in both cases




Genotype
MGI:5471803
tg2
Allelic
Composition		 Tg(Myh6-Gsk3b*)19Jusa/0
Genetic
Background		 involves: FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
decreased myocardial infarct size ( J:186597 )
• following ischemia and reperfusion
• however, treatment with rapamycin restores infarct area size
increased myocardial infarct size ( J:186597 )
• following 2 hours of ischemia without reperfusion

homeostasis/metabolism
decreased myocardial infarct size ( J:186597 )
• following ischemia and reperfusion
• however, treatment with rapamycin restores infarct area size
increased myocardial infarct size ( J:186597 )
• following 2 hours of ischemia without reperfusion




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory