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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Hnf1btm1Ics
targeted mutation 1, Mouse Clinical Institute
MGI:5471835
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Hnf1btm1Ics/Hnf1btm1Sce
Wnt4tm2(EGFP/cre)Svo/Wnt4+ 		involves: 129P2/OlaHsd MGI:5471840
cn2
 		Hnf1btm1Ics/Hnf1b+
Wnt4tm2(EGFP/cre)Svo/Wnt4+ 		involves: 129P2/OlaHsd MGI:5471841


Genotype
MGI:5471840
cn1
Allelic
Composition		 Hnf1btm1Ics/Hnf1btm1Sce
Wnt4tm2(EGFP/cre)Svo/Wnt4+
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hnf1btm1Ics mutation (0 available); any Hnf1b mutation (16 available)
Hnf1btm1Sce mutation (2 available); any Hnf1b mutation (16 available)
Wnt4tm2(EGFP/cre)Svo mutation (1 available); any Wnt4 mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, complete penetrance ( J:194051 )
• die within the first 2 days after birth

renal/urinary system
abnormal kidney morphology ( J:194051 )
• higher density of mature glomeruli in the medulla region compared to the periphery unlike in controls
renal glomerulus cyst ( J:194051 )
• 12-16% of glomeruli become cystic
abnormal metanephros morphology ( J:194051 )
• expression analysis indicates a defect in proximal and intermediate regions of the S-shaped bodies development during tubule development
• S-shaped bodies appear less convoluted
• decrease in proliferation in comma-shaped bodies and a stronger decrease in the future proximal tubule of S-shaped bodies at E16.5
• increase in apoptosis in kidney epithelium but not stroma at E16.5
• strong increase in apoptosis in late mutant nephron tubules and a more moderate increase in S-shaped bodies
hydronephrosis ( J:194051 )
• occasional
abnormal renal tubule morphology ( J:194051 )
• decrease in tubular structures
• reduction of 43.5% in mature glomeruli mutant kidneys
• higher density of mature glomeruli in the medulla region compared to the periphery unlike in controls
abnormal loop of Henle morphology ( J:194051 )
• medullar elongated loop of Henle tubules are not visible at P0

growth/size/body
renal glomerulus cyst ( J:194051 )
• 12-16% of glomeruli become cystic




Genotype
MGI:5471841
cn2
Allelic
Composition		 Hnf1btm1Ics/Hnf1b+
Wnt4tm2(EGFP/cre)Svo/Wnt4+
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hnf1btm1Ics mutation (0 available); any Hnf1b mutation (16 available)
Wnt4tm2(EGFP/cre)Svo mutation (1 available); any Wnt4 mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
renal/urinary system
renal glomerulus cyst ( J:194051 )
• in some mice
abnormal renal tubule morphology ( J:194051 )
• enlarged, more obvious at E15.5 than at P0

growth/size/body
renal glomerulus cyst ( J:194051 )
• in some mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory